Experimental evaluation of antipyretic and analgesic activities of aspartame

Tandel, Kirtida R

doi:10.4103/0253-7613.83131

Cited by 6 publications

(7 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6 Unfortunately, there continues to be controversy as to the potential health risks of these sweeteners with conclusions ranging from being unsafe to safe for human consumption. 7 The Food and Drug Administration has approved the sweeteners saccharin, aspartame, acesulfame K, sucralose, and rebaudioside A (Stevia) as dietary supplements in the U.S. 8 However, Stevia was not approved in Canada or the European communities because its metabolite steviol has been shown to be converted into several mutagenic compounds. 9 Saccharin, the forerunner of artificial sweeteners, is a cyclic sulfonamide that is not metabolized in humans and excreted predominately in urine.…”

Section: ■ Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Reaction Kinetics and Efficiencies for the Hydroxyl and Sulfate Radical Based Oxidation of Artificial Sweeteners in Water

et al. 2012

View full text Add to dashboard Cite

Over the past several decades, the increased use of artificial sweeteners as dietary supplements has resulted in rising concentrations of these contaminants being detected in influent waters entering treatment facilities. As conventional treatments may not quantitatively remove these sweeteners, radical-based advanced oxidation and reduction (AO/RP) treatments could be a viable alternative. In this study, we have established the reaction kinetics for both hydroxyl ((•)OH) and sulfate (SO(4)(•-)) radical reaction with five common artificial sweeteners, as well as their associated reaction efficiencies. Rate constants for acesulfame K, aspartame, rebaudioside A, saccharin, and sucralose were <2 × 10(7), (2.28 ± 0.02) × 10(9), (2.1 ± 0.1) × 10(8), <2 × 10(7), and (1.7 ± 0.1) × 10(8) M(-1) s(-1) for the sulfate radical, and (3.80 ± 0.27) × 10(9), (6.06 ± 0.05) × 10(9), (9.97 ± 0.12) × 10(9), (1.85 ± 0.01) × 10(9), and (1.50 ± 0.01) × 10(9) M(-1) s(-1) for the hydroxyl radical, respectively. These latter values have to be combined with their corresponding reaction efficiencies of 67.9 ± 0.9, 52.2 ± 0.7, 43.0 ± 2.5, 52.7 ± 2.9, and 98.3 ± 3.5% to give effective rate constants for the hydroxyl radical reaction that can be used in the modeling of the AOP based removal of these contaminants.

show abstract

Section: ■ Introductionmentioning

confidence: 99%

“…Adverse human health effects for the use of artificial sweeteners have been reported in numerous studies . Unfortunately, there continues to be controversy as to the potential health risks of these sweeteners with conclusions ranging from being unsafe to safe for human consumption …”

Section: Introductionmentioning

confidence: 99%

Reaction Kinetics and Efficiencies for the Hydroxyl and Sulfate Radical Based Oxidation of Artificial Sweeteners in Water

et al. 2012

View full text Add to dashboard Cite

show abstract

“…The prevalence of chronic diseases such as overweight, obesity and diabetes mellitus has increased over the last years [1]. Because of this, an alternative to reduce the energy intake from food is to replace sweetened foods and beverages by those with non-caloric substitutes, both natural and artificial [2].…”

Section: Introductionmentioning

confidence: 99%

Chronic Consumption of Sweeteners Increases Carbonylated Protein Production in Lymphocytes from Mouse Lymphoid Organs

Herrera¹,

Carrillo²,

Ramírez-Durán³

et al. 2017

EJNFS

View full text Add to dashboard Cite

Background: The prevalence of overweight, obesity and diabetes mellitus has increased in Mexico, therefore, sucralose and stevia are being used as alternative non-caloric sweeteners to reduce energy intake. Moreover, poorly balanced diets can lead to the formation of carbonyl groups, a marker used to determine oxidative damage to proteins. Increased presence of carbonylated proteins in CD1 mice chronically consuming sweeteners, may point them as causing oxidative damage. Aims: To determine whether the continued use of natural and artificial sweeteners increases the presence of carbonylated proteins in lymphocytes of lymphoid tissues in CD1 male mice. Methods: The present study was conducted with 72 CD1 newly weaned (21-day old) male mice, fed with standard lab diet and water ad libitum; mice were hosted in cages in groups of 4 under controlled temperature conditions (19-21°C), and light/dark cycles of 12/12 h. Weight and food intake was quantified weekly. Three groups of mice were randomly conformed: a) Baseline (21-day

show abstract

“…Because of the diverse pharmacological and other applications, synthesis of 4‐arylidene‐2‐phenyl‐5(4 H )‐oxazolones has been of utmost interest to organic chemists for a long time. A number of methods are available for the synthesis of 5(4 H )‐oxazolones, including the recent use of bismuth acetate and zinc chloride…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5][6] Because of the diverse pharmacological and other applications, 7 synthesis of 4-arylidene-2-phenyl-5 (4H)-oxazolones has been of utmost interest to organic chemists for a long time. A number of methods 8 are available for the synthesis of 5(4H)-oxazolones, including the recent use of bismuth acetate 9 and zinc chloride. 10 Further, microwave-assisted synthesis of these compounds 11 was found to be clearer, faster, and more economical.…”

Section: Introductionmentioning

confidence: 99%

A Facile and Efficient Synthesis of 4‐Arylidene‐2‐phenyl‐5(4H)‐oxazolones and Their Antimicrobial Evaluation against Selected Human and Phytopathogens

Voosala

Suhasini

Dasari

2016

J Chinese Chemical Soc

View full text Add to dashboard Cite

A simple and convenient method has been developed for the synthesis of a series of 2‐(4‐substituted phenyl)‐4‐(substituted arylidene)‐1,3‐oxazol‐5‐ones (5a–j) via reactions of hippuric acid with differently substituted aromatic aldehydes (4a–j) in sodium acetate, potassium acetate, calcium acetate, and ammonium acetate, respectively, which were tested for their efficiency as catalysts in both conventional and microwave‐assisted synthetic methods in presence of 4 Å zeolites. The title compounds were evaluated for their antimicrobial properties against selected human pathogens (bacterial and fungal) and phytopathogens (fungal) and were compared with standard drugs. The results of the study are reported.

show abstract

Experimental evaluation of antipyretic and analgesic activities of aspartame

Cited by 6 publications

References 4 publications

Reaction Kinetics and Efficiencies for the Hydroxyl and Sulfate Radical Based Oxidation of Artificial Sweeteners in Water

Reaction Kinetics and Efficiencies for the Hydroxyl and Sulfate Radical Based Oxidation of Artificial Sweeteners in Water

Chronic Consumption of Sweeteners Increases Carbonylated Protein Production in Lymphocytes from Mouse Lymphoid Organs

A Facile and Efficient Synthesis of 4‐Arylidene‐2‐phenyl‐5(4H)‐oxazolones and Their Antimicrobial Evaluation against Selected Human and Phytopathogens

Contact Info

Product

Resources

About