The building sector continues to play an essential role in reducing worldwide energy consumption. The reduced consumption is accompanied by stricter regulation for the thermotechnical design of the building envelope. The redefined nearly Zero Energy Building levels that will come into force for each member state will pressure designers to rethink the constructive details so that mandatory levels can be reached, without increasing the construction costs over an optimum level but at the same time reducing greenhouse gas emissions. The paper aims to illustrate the main conclusions obtained in assessing the thermo-energy performance of a steel-framed building representing a holistically designed modular laboratory located in a moderate continental temperate climate, characteristic of the south-eastern part of the Pannonian Depression with some sub-Mediterranean influences. An extensive numerical simulation of the main junctions was performed. The thermal performance was established in terms of the main parameters, the adjusted thermal resistances and global thermal insulation coefficient. Further on, the energy consumption for heating was established, and the associated energy rating was in compliance with the Romanian regulations. A parametric study was done to illustrate the energy performance of the investigated case in the five representative climatic zones from Romania. An important conclusion of the research indicates that an emphasis must be placed on the thermotechnical design of Light Steel Framed solutions against increased thermal bridge areas caused by the steel’s high thermal conductivity for all building components to reach nZEB levels. Nevertheless, the results indicate an exemplary behaviour compared to classical solutions, but at the same time, the need for an iterative redesign so that all thermo-energy performance indicators are achieved.