The paper presents the results of an experimental campaign on the behaviour of engineered masonry infill walls subjected to both in-and out-of-plane loading. The aim of the research was to develop a design approach for masonry infill walls capable of solving their vulnerability and detrimental interaction with the frame structure when exposed to seismic excitation. Tests on two large-scale specimens and sub-assemblies were performed in order to evaluate the infill deformation capacity, the damage associated with different drift levels, and the mechanical properties of the components. A design solution with sliding joints to reduce the infill-frame interaction and ensure out-of-plane stability, which was proposed in a previous study, was developed and refined with focus on construction details. The aim of sliding joints is to ensure a predetermined mechanism in the infill wall, which is governed by hierarchy of strength and is capable of ensuring ductility and energy dissipation that can be taken into account in the design practice, thanks to the predictability of the response. The two infill wall specimens, one of them including an opening, reached up to 3 % in-plane drift with very little damage and supported an out-of-plane force equivalent to a horizontal acceleration four times the acceleration of gravity. The force-displacement hysteretic curve, sliding at the joints and crack pattern show the efficiency of the construction technique, based on affordable and tradition-like construction processes and materials. The technique, presented here for hollow fired-clay masonry units, can be extended to different masonry infill typologies.