Experimental evaluation of the Dideco D903 Avant 1.7 hollow-fibre membrane oxygenator

Mueller, Xavier M.; Tevaearai, H. T.; Augstburger, Monique; Horisberger, Judith; Segesser, Ludwig K. von

doi:10.1177/026765919801300512

Cited by 5 publications

(5 citation statements)

References 9 publications

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“…When corrected by hematocrit and normalized by prebypass values, the thrombocyte count in calves exhibited a drop as soon as the mixing phase which persisted during the perfusion. Similar findings were reported in previous reports of our laboratory (12,13). Damage to thrombocytes occurs as a result of interaction of the blood with the membrane surface and shear stress within the blood.…”

Section: Discussionsupporting

confidence: 91%

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Are Standard Human Coagulation Tests Suitable in Pigs and Calves During Extracorporeal Circulation?

et al. 2001

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The thrombogenicity of membrane oxygenators as well as clotting parameters profiles, using standard human clotting tests, was analyzed in calves and pigs during 6 h perfusion. Three calves and 3 pigs were connected to extracorporeal circulation with standard heparinization. Blood samples were taken for coagulation variables throughout perfusion, and oxygenators were examined for clot deposits at the end of the experiment. Two out of 3 oxygenators of the calf group presented clot deposits while none in the pig group did. Baseline coagulation variables of pigs showed values similar to those of humans while neither extrinsic nor intrinsic pathways could be activated in calves with standard human coagulation tests. The calf model, in conclusion, was confirmed to be a difficult model for the testing of extracorporeal circulation device resistance to thrombus formation, which is, however, not reflected by standard human coagulation tests. The pig model is a better model in which both coagulation pathways could be activated with standard human coagulation tests.

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Section: Discussionsupporting

confidence: 91%

“…In conclusion, the calf model is confirmed to be a difficult model for the testing of ECC device resistance to thrombus formation (12,13). Therefore, when a device passes through the test successfully in calves, it may be applied without concern to humans, who are less thrombogenic.…”

Section: Discussionmentioning

confidence: 95%

Are Standard Human Coagulation Tests Suitable in Pigs and Calves During Extracorporeal Circulation?

et al. 2001

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“…They calculated absolute values being 255 mL/min (1.7 m 2 ) versus 270 mL/min (2 m 2 ) making the 2 m 2 one more efficient. However, when corrected for MSA, the values were 150 mL/min/m 2 (1.7 m 2 ) versus 135 mL/min/m 2 (2 m 2 ) showing more efficiency from the 1.7 m 2 oxygenator (4).…”

Section: Discussionmentioning

confidence: 91%

“…The main advantages of using membrane oxygenators are their gas exchange predictability and improved blood‐handling capabilities. Several studies have been undertaken in the past to evaluate oxygenator performance in vitro (1), ex vivo in animals (2–4), and in humans (5–9).…”

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confidence: 99%

Comparing Oxygen Transfer Performance Between Three Membrane Oxygenators: Effect of Temperature Changes During Cardiopulmonary Bypass

et al. 2007

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Recently, a new oxygenator (Dideco 903 [D903], Dideco, Mirandola, Italy) has been introduced to the perfusion community, and we set about testing its oxygen transfer performance and then comparing it to two other models. This evaluation was based on the comparison between oxygen transfer slope, gas phase arterial oxygen gradients, degree of blood shunting, maximum oxygen transfer, and diffusing capacity calculated for each membrane. Sixty patients were randomized into three groups of oxygenators (Dideco 703 [D703], Dideco; D903; and Quadrox, Jostra Medizintechnik AG, Hirrlingen, Germany) including 40/20 M/F of 68.6 +/- 11.3 years old, with a body weight of 71.5 +/- 12.1 kg, a body surface area (BSA) of 1.84 +/- 0.3 m(2), and a theoretical blood flow rate (index 2.4 times BSA) of 4.4 +/- 0.7 L/min. The maximum oxygen transfer (VO(2)) values were 313 mL O(2)/min (D703), 579 mL O(2)/min (D903), and 400 mL O(2)/min (Quadrox), with the D903 being the most superior (P < 0.05). Oxygen (O(2)) gradients were 320 mm Hg (D703), 235 mm Hg (D903), and 247 mm Hg (Quadrox), meaning D903 and Quadrox are more efficient versus the D703 (P < 0.05). Shunt fraction (Qs/Qt) and diffusing capacity (DmO(2)) were comparable (P = ns). Diffusing capacity values indexed to BSA (DmO(2)/m(2)) were 0.15 mL O(2)/min/mm Hg/m(2) (D703), 0.2 mL O(2)/min/mm Hg/m(2) (D903), and 0.18 mL O(2)/min/mm Hg/m(2) (Quadrox) with D903 outperforming D703 (P < 0.0005). During hypothermia (32.0 +/- 0.3 degrees C), there was a lower absolute and relative VO(2 )for all three oxygenators (P = ns). The O(2) gradients, DmO(2) and DmO(2)/m(2), were significantly lower for all oxygenators (P < 0.01). Also, Qs/Qt significantly rose for all oxygenators (P < 0.01). The oxygen transfer curve is characteristic to each oxygenator type and represents a tool to quantify oxygenator performance. Using this parameter, we demonstrated significant differences among commercially available oxygenators. However, all three oxygenators are considered to meet the oxygen needs of the patients.

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“…The typical industrial design approach is largely based on time-consuming and often inefficient empirical approaches, and the device fluid dynamics is mainly investigated using experimental techniques (Fiore et al 1998; Mueller et al 1998; Kawahito et al 2001). …”

Section: Introductionmentioning

confidence: 99%

Computational evaluation of the thrombogenic potential of a hollow-fiber oxygenator with integrated heat exchanger during extracorporeal circulation

Pelosi

Sheriff

Stevanella

et al. 2012

Biomech Model Mechanobiol

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The onset of thromboembolic phenomena in blood oxygenators, even in the presence of adequate anticoagulant strategies, is a relevant concern during extracorporeal circulation (ECC). For this reason, the evaluation of the thrombogenic potential associated with extracorporeal membrane oxygenators should play a critical role into the preclinical design process of these devices. This study extends the use of computational fluid dynamics simulations to guide the hemodynamic design optimization of oxygenators and evaluate their thrombogenic potential during ECC. The computational analysis accounted for both macro- (i.e., vortex formation) and micro-scale (i.e., flow-induced platelet activation) phenomena affecting the performances of a hollow-fiber membrane oxygenator with integrated heat exchanger. A multiscale Lagrangian approach was adopted to infer the trajectory and loading history experienced by platelet-like particles in the entire device and in a repetitive subunit of the fiber bundles. The loading history was incorporated into a damage accumulation model in order to estimate the platelet activation state (PAS) associated with repeated passes of the blood within the device. Our results highlighted the presence of blood stagnation areas in the inlet section that significantly increased the platelet activation levels in particles remaining trapped in this region. The order of magnitude of PAS in the device was the same as the one calculated for the components of the ECC tubing system, chosen as a term of comparison for their extensive diffusion. Interpolating the mean PAS values with respect to the number of passes, we obtained a straightforward prediction of the thrombogenic potential as a function of the duration of ECC.

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Experimental evaluation of the Dideco D903 Avant 1.7 hollow-fibre membrane oxygenator

Cited by 5 publications

References 9 publications

Are Standard Human Coagulation Tests Suitable in Pigs and Calves During Extracorporeal Circulation?

Are Standard Human Coagulation Tests Suitable in Pigs and Calves During Extracorporeal Circulation?

Comparing Oxygen Transfer Performance Between Three Membrane Oxygenators: Effect of Temperature Changes During Cardiopulmonary Bypass

Computational evaluation of the thrombogenic potential of a hollow-fiber oxygenator with integrated heat exchanger during extracorporeal circulation

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