This paper conducts a numerical simulation of the antiseismic performance for single-layer masonry structures, completes a study on crack distributions and detailed characteristics of masonry structures, and finally verifies the correctness of the numerical model by experimental tests. This paper also provides a reinforced proposal to improve the antiseismic performance of single-layer masonry structures. Results prove that the original model suffers more serious damage than the reinforced model; in particular, longitudinal cracks appear on bottoms of two longitudinal walls in the original model, while these cracks appear later in the reinforced model; a lot of cracks appear on the door hole of the original model, and no crack appears in the reinforced model till the end of seismic waves; seismic damage of walls in the reinforced model is obviously lighter than that in the original model; dynamic responses at all observed points of the reinforced masonry are obviously less than those of the original model. Strains at all positions of the reinforced model are obviously smaller than those of the original model. From macroscopic and microscopic perspectives, the computational results prove that the reinforced proposal proposed in this paper can effectively improve the antiseismic performance of the masonry structure.