Experimental Evidence for Histamine Release in Allergy

Katz, Gerhard

doi:10.1001/jama.1941.02820470030008

Cited by 127 publications

(20 citation statements)

References 6 publications

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“…An increase in total blood histamine due to a high level in the plasma, such as occurs in experimental allergic reactions (22,23), has a significance quite different from that of an increase due to a rise in the numbers of basophils or eosinophils. The latter may, of course, indicate disordered histamine metabolism, since the cells may be numerous because there are increased quantities of histamine to be transported, but equally the blood histamine may only be raised because the numbers of basophils and eosinophils have increased, which may be for some reason unconnected with histamine metabolism.…”

Section: Histaminementioning

confidence: 97%

Histamine and 5-Hydroxytryptamine in the Blood of Infants and Children

Mitchell¹,

Cass²

1959

J. Clin. Invest.

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Section: Histaminementioning

confidence: 97%

Histamine and 5-Hydroxytryptamine in the Blood of Infants and Children

Mitchell¹,

Cass²

1959

J. Clin. Invest.

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“…The allergic response clearly involves the action of mediators released from mast cells and/or basophils upon exposure to the appropriate antigen (1)(2)(3)(4). Frequently, however, the symptoms of rhinitis, urticaria, or asthma cannot be related directly to allergen exposure.…”

Section: Introductionmentioning

confidence: 99%

Nasal challenge with cold, dry air results in release of inflammatory mediators. Possible mast cell involvement.

et al. 1985

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The purpose of our study was to assess the effect of cold, dry air (CDA) on the nasal mucosa of selected individuals in relation to the release of inflammatory mediators associated with mast cells. 12 subjects with a history of nasal symptoms of rhinorrhea and congestion upon cold or dry environmental exposure were challenged by nasal breathing of CDA and warm, moist air (WMA). Each subject was tested on two occasions with the order of the challenges reversed. Symptom scores were recorded, and the levels of histamine, prostaglandin (PG) D2, kinins, and 1H1-N-a-tosyl-L-arginine methyl ester (TAME)-esterase activity in nasal lavage fluids were measured.CDA caused a significant increase in mediator levels and in symptom scores as compared to baseline or to WMA. No significant increase in symptom scores or mediators was noted after WMA challenge, with the exception of a marginal increase in kinins. The response to CDA was similar, regardless of challenge order. Changes in mediators correlated with one another, and symptom scores correlated significantly with the levels of histamine, kinins, and PGD2. Five subjects without a history of nasal symptoms on cold air exposure had no change in mediators or symptom scores after CDA or WMA challenge. We conclude that CDA causes the release of inflammatory mediators possibly associated with mast cells and speculate that such a mechanism may be involved in the bronchospasm induced by CDA in asthmatics.

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“…The fact that both horse serum and egg-white possess the property of releasing histamine extends this similarity, particularly since Katz & Cohen (1941) have shown that specific allergens which have no effect on blood from normal subjects release histamine from blood of patients with the specific sensitivities. Also, Schild, Hawkins, Mongar & Herxheimer (1951) and Rosa & McDowall (1951) have recently demonstrated histamine release from isolated asthmatic human bronchial tissue in response to the specific allergen.…”

Section: Discussionmentioning

confidence: 90%