Experimental Glaucoma in Monkeys

Kalvin, Nicholas H.; Hamasaki, D.I.; Gass, J. Donald M.

doi:10.1001/archopht.1966.03850010096018

Cited by 37 publications

(3 citation statements)

References 6 publications

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“…[151617] Similarly, Kalvin and colleagues, on latex injection with raised intraocular pressure in monkeys, found poor filling primarily in the peripapillary choroid. [18] De Freitas and Morin studied 25 glaucomatous albino rabbits with raised intraocular pressure, after injection of India ink or latex, and found parapapillary choroidal filling defects of variable size in all glaucomatous eyes. [19] In clinical studies, Laatikainen described that 60% of glaucomatous eyes with moderately controlled intraocular pressure showed delayed or deficient filling of the peripapillary choriocapillaris.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological correlation of parapapillary atrophy in monkeys with experimental glaucoma and temporary central retinal artery occlusion

Jonas

Hayreh

Tao

2014

Indian J Ophthalmol

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Objective:To investigate the clinicopathological correlation of parapapillary atrophy.Materials and Methods:The study included 16 eyes of rhesus monkeys (Macaca mulatta) – 4 eyes with experimental glaucoma, 11 eyes after experimental temporary occlusion of the central retinal artery, and 1 normal eye. On histological sections, we measured zones with different histological characteristics. On fundus photographs, alpha zone and beta zone of parapapillary atrophy were measured and correlated with the histological data.Results:The size of the clinical alpha zone of parapapillary atrophy was significantly correlated with the size of the histological region with irregularities of the retinal pigment epithelium (P = 0.05; correlation coefficient r = 0.49) and with the size of the histological region with a decreased density of retinal photoreceptors (P = 0.01; r = 0.60). The size of clinical beta zone of parapapillary atrophy significantly correlated with the size of the histological region with complete loss of the retinal pigment epithelium (P <0.001; r = 0.91), with the size of the histological zone with a complete loss of photoreceptors (P <0.001; r = 0.81), and with the size of the histological zone with a closed choriocapillaris (P <0.001; r = 0.89).Conclusions:The clinically seen alpha zone of parapapillary atrophy correlates with histological parapapillary irregularities of the retinal pigment epithelium and decreased density of retinal photoreceptors. The clinically seen beta zone of parapapillary atrophy correlates with histological complete loss of the retinal pigment epithelium and of the photoreceptors, and a closure of the choriocapillaris.

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Section: Discussionmentioning

confidence: 99%

Clinicopathological correlation of parapapillary atrophy in monkeys with experimental glaucoma and temporary central retinal artery occlusion

Jonas

Hayreh

Tao

2014

Indian J Ophthalmol

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“…De Carvalho (1962) injected cotton fragments into rabbit anterior chambers, which elevated IOP to 38-40 mm Hg; in those animals in which the glaucoma persisted longer than 30 days, retinal and optic disc pathology was observed. Injection of talcum powder or dental cement (Kalvin et al, 1966b) produced elevated IOP in monkeys.…”

Section: A Experimental Glaucomamentioning

confidence: 95%

Animals in Ophthalmic Research: Concepts and Methodologies

Peiffer¹,

Armstrong²,

Johnson³

1981

Methods of Animal Experimentation

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“…Some of the procedures described previously include : replacement of aqueous humor with methylcellulose ( 1 ), subconjunctival injection of phenol (2), placement of polyethylene tubing in the angle of the anterior chamber ( 3 ) , injection of alpha-chymotrypsin into the posterior chamber (4) and "water loading" animals via gastric intubation ( 5 ) . None of these methods fulfilled all of the criteria for an optimal test system.…”

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confidence: 99%