Experimental Hepatotoxicity

Zimmerman, Hyman J.

doi:10.1007/978-3-642-45483-7_1

Cited by 18 publications

(15 citation statements)

References 317 publications

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“…The most common view is that necrotic cells leak enzymes to the plasma; increased plasma activity, however, has been demonstrated in diseases with little or no tissue necrosis, e.g. in anoxia (12). In the present study we found elevated plasma activity during the first 2 days after hepatectomy.…”

Section: Discussioncontrasting

confidence: 43%

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One sample antipyrine clearance after 90% partial hepatectomy in the rat

Poulsen

1985

Liver

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ABSTRACT— Antipyrine clearance was estimated by a one‐sample saliva technique before and after 90% partial hepatectomy in nine rats. For comparison, the hepatic contents of cytochrome P450 and serum alanine amino transaminase activity were determined in vitro. Antipyrine clearance and hepatic cytochrome P450 were reduced according to the reduction in liver weight following hepatectomy. During hepatic regeneration, antipyrine clearance and liver weight increased identically, whereas total cytochrome P450 recovered more slowly, being 71% of initial values at the time when antipyrine clearance and liver weight had recovered. Serum alanine amino transferase activity increased 10–20 times 24 h after hepatectomy, and normalized after 52 h. The hepatic glutathione content per gram liver weight was unchanged during the regeneration, suggesting intact detoxification during hepatic regeneration. This study demonstrates that, although the assessment requires some time, and that a value cannot be attached to a fixed time‐point, the one‐sample antipyrine saliva clearance is a quantitative in vivo estimate of ‘functional hepatic mass’. The test can easily be applied in animal studies where such a measure is requested.

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Section: Discussioncontrasting

confidence: 43%

“…Plasma activity of alanine amino transferase is widely used to evaluate liver damage, since it was demonstrated that hepatic damage leads to increased activity in serum (12). The basis for this increased activity is largely unknown.…”

Section: Discussionmentioning

confidence: 99%

One sample antipyrine clearance after 90% partial hepatectomy in the rat

Poulsen

1985

Liver

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“…Adanya metabolit reaktif tersebut dapat merangsang terjadinya peningkatan hidroperoksida dan malondialdehid, yang lebih lanjut dapat menurunkan jumlah glutation secara signifikan di dalam jaringan hepar (Al Wasel dan Bashandy, 2011). Lebih lanjut terjadi perubahan drastis di dalam hati seperti perubahan lemak, degenerasi melemak (Nirmala, et al, 2012) serta infiltrasi sel inflamasi, yang berdampak terjadinya steatosis dan pelepasan enzim transaminase (Zimmerman, 1999;Timbrel, 2008, Gupta et al, 2004. Kenaikan aktivitas ALP sebesar 1,6-2 kali nilai normal juga terjadi akibat pemejanan karbon tetraklorida pada tikus (Weatherby and Ferguson, 2002;Mukherjee, 2002;Rajendran et al, 2009;Panjaitan et al, 2007).…”

Section: Hasil Dan Pembahasanunclassified

Efek Proteksi Dekokta Kulit Alpukat Pada Hepar Tikus Terinduksi Karbon Tetraklorida

et al. 2016

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“…Continuous exposure to a variety of environmental toxic agents enhances hepatic injury. 1 A growing interest has emerged around the globe in rediscovering medicinal plants as useful therapeutic agents for the prevention of such injury. Successful liver therapy owes much to the identification of pathogenesis and elaboration of suitable models of hepatic injury, comparable to those encountered in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

Role of plant metabolites in toxic liver injury

Gole

Dasgupta

2002

Asia Pac J Clin Nutr

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Aphanamixis polystachya is a traditional medicinal plant of the Meliaceae family in India. A crude ethanolic extract of the leaf of this plant shows a beneficial effect on toxic liver injury. Its antihepatotoxic activity was evaluated on carbon tetrachloride (CCl4)-induced liver injury in a rat model. The assessment of hepatoprotective activity was evaluated by measuring the activities of aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT), alkaline phosphatase (ALP), acid phosphatase (ACP) and lactate dehydrogenase (LDH), serum total bilirubin and albumin and histology of the liver. The crude leaf extract significantly inhibits the enhanced ASAT, ALAT, ALP, ACP and LDH activities released from the CCl4-intoxicated animals. It also ameliorated the depressed value of serum albumin and the enhanced value of total bilirubin in plasma caused by CCl4 intoxication. The study showed that the crude ethanolic extract from A. polystachya leaves provided protection against acute carbon tetrachloride-induced liver damage.

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Experimental Hepatotoxicity

Cited by 18 publications

References 317 publications

One sample antipyrine clearance after 90% partial hepatectomy in the rat

One sample antipyrine clearance after 90% partial hepatectomy in the rat

Efek Proteksi Dekokta Kulit Alpukat Pada Hepar Tikus Terinduksi Karbon Tetraklorida

Role of plant metabolites in toxic liver injury

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