Experimental hypothyroidism during pregnancy affects nociception and locomotor performance of offspring in rats

Alves, Iura Gonzalez Nogueira; Cruz, Kamilla M.L.; Mota, Clarissa M.D.; Santana, Demetrius Silva de; Gaujac, Danielle Pereira; Carvalho, Vanessa Cibelle Barboza de; Reis, L. C.; Sluka, Kathleen A.; Quintans‐Júnior, Lucindo José; Antoniolli, Ângelo Roberto; DeSantana, Josimari Melo; Badauê‐Passos, Daniel; Santana‐Filho, Valter Joviniano

doi:10.1002/j.1532-2149.2013.00306.x

Cited by 13 publications

(7 citation statements)

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“…The pain sensitivity has been documented to be related with thyroid status [4]. An adequate support of maternal thyroid hormones may be required to ensure a normal nociceptive function of offspring into adulthood [5]. However, information regarding the underlying mechanism of thyroid hormones in affecting pain processing and synaptic transmission in the anterior cingulate cortex (ACC), which is highly involved in the pain modulation, is limited.…”

Section: Introductionmentioning

confidence: 99%

Decreased Pain Threshold and Enhanced Synaptic Transmission in the Anterior Cingulate Cortex of Experimental Hypothyroidism Mice

Zheng

Zhang

et al. 2014

Mol Pain

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BackgroundThyroid hormones are essential for the maturation and functions of the central nervous system. Pain sensitivity is related to the thyroid status. However, information on how thyroid hormones affect pain processing and synaptic transmission in the anterior cingulate cortex (ACC) is limited. Nociceptive threshold and synaptic transmission in the ACC were detected in the experimental hypothyroidism (HT) mice.ResultsHT was induced by methimazole and potassium perchlorate in distilled drinking water for 4 weeks. The threshold of pain perception to hot insults, but not mechanical ones, decreased in hypothyroid mice. After treatment with tri-iodothyronine (T3) or thyroxine (T4) for 2 weeks, thermal pain threshold recovered. Electrophysiological recordings revealed enhanced glutamatergic synaptic transmission and reduced GABAergic synaptic transmission in the ACC. Supplementation with T3 or T4 significantly rescued this synaptic transmission imbalance. In the same model, HT caused the up-regulation of the GluR1 subunit of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor and NR2B-containing N-methyl-D-aspartate receptors, but it down-regulated γ-aminobutyric acid A receptors in the ACC. Supplementation with T3 or T4 notably recovered the levels of above proteins.ConclusionsThese results suggest that HT promotes hypersensitivity to noxious thermal, and that supplementation with T3 or T4 rescues the imbalance between excitatory and inhibitory transmission in the ACC.

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Section: Introductionmentioning

confidence: 99%

Decreased Pain Threshold and Enhanced Synaptic Transmission in the Anterior Cingulate Cortex of Experimental Hypothyroidism Mice

Zheng

Zhang

et al. 2014

Mol Pain

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“…Sufficient maternal thyroid hormones may be necessary to determine a normal nociceptive function of offspring. 14 Previous study showed that hypersensitivity may alter motor coordination, and avoidance behaviour. 15…”

Section: Perinatal Hypothyroidism Decreased Nociceptive Thresholdmentioning

confidence: 99%

Perinatal Propylthiouracil-Induced Hypothyroidism Impaired Motor Coordination in Adult Female Offspring

Khairinisa

Takatsuru²,

Amano

et al. 2019

Pharmacology and Clinical Pharmacy Research (PCPR) is an intern

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Thyroid hormone (TH) play crucial roles in the growth and development of brain. Efficiency of TH during the perinatal period results in severe mental and physical retardation, known as cretinism in humans. Animal models have largely focused on mild and severe hypothyroidism associated with deficits in body weight, developmental delays, and cognitive deficits. Although various behavioral analyses have been reported, the effect of perinatal hypothyroidism in adult female mice has not been clarified. The aim of this study was to examine whether propylthiouracil (PTU)-induced hypothyroidism could impair motor coordination in female offspring. We used C57BL/6j mice and divided them into three groups based on the dose of PTU which was applied during perinatal period (embryonic day-14 to postnatal day-14); control, 5 ppm, and 50 ppm groups. We observed motor coordination function and additional nociceptive test in female offspring. We found that motor coordination and nociceptive threshold were affected in 50 ppm groups. We concluded that the moderate hypothyroidism could impair motor coordination in adult offspring.

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“…In athyreotic patients, the pain sensitivity was associated with the thyroid status [61] . It has also been reported that an adequate supply of thyroid hormones from mother rats is necessary to acquire a normal nociceptive function in the offspring into adulthood [62] . Using experimental hypothyroidism mice that were treated with potassium perchlorate and methimazole in the drinking water, it was investigated whether and how synaptic transmission and pain perception in the ACC are modulated by thyroid hormones [63] .…”

Section: Hypothyroidismmentioning

confidence: 99%

Presynaptic mechanisms at prefrontal synapses involved in persistent pain

Toyoda¹

2018

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The cumulative evidence from animal and human studies revealed that the anterior cingulate cortex (ACC) plays essential roles in pain sensation and persistent pain. It has been evident in the ACC synapses of animals that changes in both the presynaptic and postsynaptic function are caused by peripheral nerve injury. Thus far, postsynaptic changes in the ACC following nerve injury have been primarily studied to understand the mechanisms of chronic pain. In recent years, studies focusing on the presynaptic mechanisms in chronic pain have been progressively increased. In this review, I will discuss molecular mechanisms associated with chronic pain and presynaptic form of long-term potentiation. I will also discuss evidence for presynaptic changes in the ACC caused by disease-related pain.

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Experimental hypothyroidism during pregnancy affects nociception and locomotor performance of offspring in rats

Abstract: EGH promotes hypersensitivity to noxious thermal but not mechanical stimulus. Moreover, motor force is similarly reduced in male and female OMTDs, whereas motor performance is reduced only in mature male OMTD, suggesting the presence of a protective factor in females.

Cited by 13 publications

References 50 publications

Decreased Pain Threshold and Enhanced Synaptic Transmission in the Anterior Cingulate Cortex of Experimental Hypothyroidism Mice

Decreased Pain Threshold and Enhanced Synaptic Transmission in the Anterior Cingulate Cortex of Experimental Hypothyroidism Mice

Perinatal Propylthiouracil-Induced Hypothyroidism Impaired Motor Coordination in Adult Female Offspring

Presynaptic mechanisms at prefrontal synapses involved in persistent pain

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