Experimental immunology Modulatory effects of bestatin on T and B lymphocyte subsets and the concentration of cytokines released by Th1/Th2 lymphocytes in cyclophosphamide-treated mice

Lis, Magdalena; Obmińska-Mrukowicz, Bożena

doi:10.5114/ceji.2013.34357

Cited by 7 publications

(5 citation statements)

References 30 publications

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“…Previous studies have shown that immunoregulatory selenium-enriched peptides from soybean can restore the CTX-induced decrease of WBCs [ 43 ]. Lis et al [ 44 ] revealed that a low molecular weight dipeptide bestatin significantly improved the CTX-induced decrease in the number of peripheral blood LYM. These results indicated that the administration of CBH and HD restored normal blood indices, implying that CBH and HD protect against immunosuppression induced by CTX.…”

Section: Resultsmentioning

confidence: 99%

Immunomodulatory Effects of Chicken Broth and Histidine Dipeptides on the Cyclophosphamide-Induced Immunosuppression Mouse Model

Zhang

Wang

et al. 2022

Nutrients

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The carnosine and anserine, which represent histidine dipeptides (HD), are abundant in chicken broth (CB). HD are endogenous dipeptide that has excellent antioxidant and immunomodulatory effects. The immunomodulatory effect of CB hydrolysate (CBH) and HD in cyclophosphamide (CTX)-induced immunosuppressed mice was examined in this study. CBH and HD were given to mice via oral gavage for 15 days, accompanied by intraperitoneal CTX administration to induce immunosuppression. CBH and HD treatment were observed to reduce immune organ atrophy (p < 0.05) and stimulate the proliferation of splenic lymphocytes (p < 0.05) while improving white blood cell, immunoglobulin M (IgM), IgG, and IgA levels (p < 0.05). Moreover, CBH and HD strongly stimulated interleukin-2 (IL-2) and interferon-gamma (IFN-γ) production by up-regulating IL-2 and IFN-γ mRNA expression (p < 0.05) while inhibiting interleukin-10 (IL-10) overproduction and IL-10 mRNA expression (p < 0.05). In addition, CBH and HD prevented the inhibition of the nitric oxide (NP)/cyclic guanosine monophosphate-cyclic adenosine monophosphate (cGMP-cAMP)/protein kinase A (PKA) signaling pathway (p < 0.05). These results indicate that CBH and HD have the potential to prevent immunosuppression induced by CTX. Our data demonstrate that CBH can effectively improve the immune capacity of immunosuppressed mice similar to the same amount of purified HD, which indicates that CBH plays its role through its own HD.

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Section: Resultsmentioning

confidence: 99%

Immunomodulatory Effects of Chicken Broth and Histidine Dipeptides on the Cyclophosphamide-Induced Immunosuppression Mouse Model

Zhang

Wang

et al. 2022

Nutrients

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“…In this report, the cyclophosphamideinduced immunosuppression was verified by means of cytokines production both in vitro and in vivo. In other report, cyclophosphamide-induced immune modulation changes T and B lymphocyte subsets and increases cytokines release by Th1/Th2 lymphocytes in mice model [13] . After treatment with PME, rats had better body and organs weight compared to cyclophosphamide-treated group.…”

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confidence: 79%

“…Based on the evaluation of immunity, cyclophosphamide-induced immunomodulated mice exhibited significant immune-related differences compared to untreated mice, such as reduced activity of splenocytes, and repressed productions of TNF-α, IL-2 and IL-12 in serum and in splenocytes, suggesting that cyclophosphamide is a potent immunomodulators [12,13] . Moreover spleen of normal and immunodeficient mice displayed significant changes in IFN-γ mRNA expression [14] .…”

mentioning

confidence: 99%

Immunomodulating Properties of Polygonum multiflorum Extracts on Cyclophosphamide-induced Immunosuppression Model

Yang¹,

Kim²,

Kang³

et al. 2018

pharmaceutical-sciences

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Yang et al.: Immunostimulation by Polygonum multiflorum extractsThe objective of the present study was to investigate the immunomodulating property of Polygonum multiflorum extracts using various in vitro and in vivo tests. In this study, Polygonum multiflorum extracts were shown to exhibit immunomodulating activities such as cytokine production in normal rat splenocyte and cyclophosphamide-induced immunosuppression model. The immunostimulant effects of Polygonum multiflorum extracts were further tested for various immunological markers. Polygonum multiflorum extracts significantly enhanced cytokines production activity in rat splenocyte. Consistently oral administration of Polygonum multiflorum extracts enhanced blood cytokine production and ameliorated spleen damage in cyclophosphamide immunosuppressed rat. In conclusion, the present investigation revealed that Polygonum multiflorum extracts possessed immunomodulating and immunostimulating properties.

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“…In addition, the occurrence of immune dysfunction seems to be regulated by IFN-γ and IL-4 levels, and the decrease of their levels may lead to impaired immune function 23 . Studies have shown that CYP, as an effective immunosuppressant, can induce the decrease of IFN-γ and IL-4 levels, thus destroying immune homeostasis and leading to immunosuppression 24 . It is worth noting that B. coagulans MZY531 treatment significantly increases the levels of IFN-γ and IL-4 and increases the expression of immune-related cytokines, including IgG, IgM, IgA, and IgE.…”

Section: Discussionmentioning

confidence: 99%

Bacillus coagulans MZY531 alleviates intestinal mucosal injury in immunosuppressive mice via modulating intestinal barrier, inflammatory response, and gut microbiota

Zhao

Sun

Cui

et al. 2023

Sci Rep

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Bacillus coagulans has a potential role in improving intestinal injury. However, the specific mechanism is still unclear. In this study, the protective effect of B. coagulans MZY531 on intestinal mucosa injury in cyclophosphamide (CYP)-induced immunosuppressed mice were investigated. The results indicated that the immune organ (thymus and spleen) indices of B. coagulans MZY531 treatment groups were significantly increased compared to the CYP group. B. coagulans MZY531 administration promotes the expression of immune proteins (IgA, IgE, IgG, and IgM). B. coagulans MZY531 could upregulate the ileum levels of IFN-γ, IL-2, IL-4, and IL-10 in immunosuppressed mice. Moreover, B. coagulans MZY531 restores the villus height and crypt depth of the jejunum and alleviates injury of intestinal endothelial cells caused by CYP. Furthermore, the western blotting results showed that B. coagulans MZY531 ameliorated CYP-induced intestinal mucosal injury and inflammatory via up-regulates the ZO-1 pathway and down-regulates the expression of the TLR4/MyD88/NF-κB pathway. After treatment with B. coagulans MZY531, the relative abundance of Firmicutes phylum was dramatically increased, as well as the genera of Prevotella and Bifidobacterium, and reducing harmful bacteria. These findings suggested that B. coagulans MZY531 has a potential immunomodulatory activity on chemotherapy-induced immunosuppression.

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Experimental immunology Modulatory effects of bestatin on T and B lymphocyte subsets and the concentration of cytokines released by Th1/Th2 lymphocytes in cyclophosphamide-treated mice

Cited by 7 publications

References 30 publications

Immunomodulatory Effects of Chicken Broth and Histidine Dipeptides on the Cyclophosphamide-Induced Immunosuppression Mouse Model

Immunomodulatory Effects of Chicken Broth and Histidine Dipeptides on the Cyclophosphamide-Induced Immunosuppression Mouse Model

Immunomodulating Properties of Polygonum multiflorum Extracts on Cyclophosphamide-induced Immunosuppression Model

Bacillus coagulans MZY531 alleviates intestinal mucosal injury in immunosuppressive mice via modulating intestinal barrier, inflammatory response, and gut microbiota

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