Experimental Infection of Gibbons with Rhinovirus

Pinto, Carl A.; Haff, R. F.

doi:10.1038/2241310a0

Cited by 31 publications

(14 citation statements)

References 6 publications

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“…The major symptoms of a typical cold last 7 days, but virus is shed for 2 weeks (31, 43). Although human rhinoviruses spread easily among animals only the higher primates are susceptible (28,29,99).…”

Section: Introductionmentioning

confidence: 99%

Replication of rhinoviruses

Butterworth

Grunert

Korant

et al. 1976

Archives of Virology

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Section: Introductionmentioning

confidence: 99%

Replication of rhinoviruses

Butterworth

Grunert

Korant

et al. 1976

Archives of Virology

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“…One of the main issues confronting mouse model development was that HRVs have a high degree of species specificity. To our knowledge, there are no known murine rhinoviruses, and the major group HRVs cannot bind to ICAM-1 from other species, with the probable exception of chimpanzees and gibbons2223). However, transfection of chimeric human/mouse ICAM-1 in vitro rendered mouse respiratory cells susceptible to HRV16, a major group HRV, infection.…”

Section: Murine Model Of Hrv Infectionmentioning

confidence: 99%

Rhinovirus and childhood asthma: an update

Song

2016

Korean J Pediatr

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Asthma is recognized as a complex disease resulting from interactions between multiple genetic and environmental factors. Accumulating evidence suggests that respiratory viral infections in early life constitute a major environmental risk factor for the development of childhood asthma. Respiratory viral infections have also been recognized as the most common cause of asthma exacerbation. The advent of molecular diagnostics to detect respiratory viruses has provided new insights into the role of human rhinovirus (HRV) infections in the pathogenesis of asthma. However, it is still unclear whether HRV infections cause asthma or if wheezing with HRV infection is simply a predictor of childhood asthma. Recent clinical and experimental studies have identified plausible pathways by which HRV infection could cause asthma, particularly in a susceptible host, and exacerbate disease. Airway epithelial cells, the primary site of infection and replication of HRV, play a key role in these processes. Details regarding the role of genetic factors, including ORMDL3, are beginning to emerge. This review discusses recent clinical and experimental evidence for the role of HRV infection in the development and exacerbation of childhood asthma and the potential underlying mechanisms that have been proposed.

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“…HRVs are exquisitely species-specific. The only nonhuman primate able to be productively infected by major class HRVs is the chimpanzee [95e99], although the gibbon has also been reported to be able to be infected [100,101]. Chimpanzees are an endangered species, and the restrictions placed on research with chimpanzees makes their use unrealistic based on ethical reasons.…”

Section: Animal Models Of Rhinovirus Infectionmentioning

confidence: 99%

Utility of animal and in vivo experimental infection of humans with rhinoviruses in the development of therapeutic agents for viral exacerbations of asthma and chronic obstructive pulmonary disease

Vecchio

Branigan

Barnathan

et al. 2015

Pulmonary Pharmacology & Therapeutics

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There is an association with acute viral infection of the respiratory tract and exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Although these exacerbations are associated with several types of viruses, human rhinoviruses (HRVs) are associated with the vast majority of disease exacerbations. Due to the lack of an animal species that is naturally permissive for HRVs to use as a facile model system, and the limitations associated with animal models of asthma and COPD, studies of controlled experimental infection of humans with HRVs have been used and conducted safely for decades. This review discusses how these experimental infection studies with HRVs have provided a means of understanding the pathophysiology underlying virus-induced exacerbations of asthma and COPD with the goal of developing agents for their prevention and treatment.

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Experimental Infection of Gibbons with Rhinovirus

Cited by 31 publications

References 6 publications

Replication of rhinoviruses

Replication of rhinoviruses

Rhinovirus and childhood asthma: an update

Utility of animal and in vivo experimental infection of humans with rhinoviruses in the development of therapeutic agents for viral exacerbations of asthma and chronic obstructive pulmonary disease

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