Experimental Infection of Inbred Mice with Herpes Simplex Virus Type 1. I. Investigation of Humoral and Cellular Immunity and of Interferon Induction

Zawatzky, Rainer; Hilfenhaus, J.; Marcucci, Fabrizio; Kirchner, Holger

doi:10.1099/0022-1317-53-1-31

Cited by 79 publications

(42 citation statements)

References 20 publications

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“…infection (Lopez, 1983: Mogensen & Kerzel Andersen, 1978Zawatzky et al, 1979). We have also presented evidence indicating that the interferon endogenously produced in response to HSV may be instrumental in mediating genetic resistance to HSV in mice (Zawatzky et al, 1981) and that this interferon is a product of macrophages (Kirchner et al, 1983). We wish to discuss our present findings in view of these results.…”

Section: Discussioncontrasting

confidence: 41%

“…On the other hand, several groups have reported that homozygous nude mice do not differ in HSV-induced primary mortality when compared to their heterozygous littermates (Lopez, 1983 ;Mogensen & Kerzel Andersen, 1978 ;Zawatzky et al, 1979). In other HSV infections, however, an increased mortality of nu/nu mice has been reported (Kapoor et al, 1982a, b: Metcalf et al, 1979Nagafuchi et al, 1979) and, of course, nude mice show a defect in specific immunity against HSV (Burns et al, 1975 ;Hilfenhaus et al, 1981). Welsh (1981) has suggested that the natural killer (NK) cell system plays a role in antiviral resistance.…”

Section: Introductionmentioning

confidence: 99%

“…For interferon measurements, a one-step assay utilizing L cells and vesicular stomatitis virus was used. All details of this technique have been previously described (Zawatzky et al, 1981 ). lnterferon-y in spleen cell supernatant was assayed by the same method.…”

Section: Micementioning

confidence: 99%

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Injection of Anti-thy-1.2 Serum Breaks Genetic Resistance of Mice against Herpes Simplex Virus

Chmielarczyk¹,

Engler²,

Ernst³

et al. 1985

Journal of General Virology

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SUMMARYNude mice have been shown to be as resistant to intraperitoneal infection with herpes simplex virus type 1 (HSV) as their heterozygous littermates. Here we document that both activation of natural killer (NK) cells and interferon induction were normal in nu/nu mice after injection of HSV. Injection of silica caused increased mortality by HSV in C57BL/6 mice. Silica, in addition, led to a significant reduction of NK cell activity but had no effect on the interferon response. Treatment of C57BL/6 mice with anti-asialo GM1 (an antiserum with a predominant effect on NK cells) caused complete abolition of the NK cell response, but had no effect on interferon induction or virus-induced mortality. In further studies a monoclonal anti-thy-1.2 antibody was utilized which possessed high activity in rivo in depleting T cell responses in mice. Injection of anti-thy-1.2 decreased NK cell activation but was without effect on the interferon response. Unexpectedly, in view of the data in nu/nu mice, this antibody increased HSV-induced mortality in C57BL/6 mice. Similar data were obtained when anti-thy-l.2 was injected into nu/nu mice. Our results are compatible with the hypothesis that T cell precursors sensitive to anti-thy-1.2 present in homozygous nude mice play a role in resistance against HSV. Furthermore, the data in the euthymic mice may indicate a role of T cells in the primary resistance of mice against HSV.

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Section: Discussioncontrasting

confidence: 41%

Section: Introductionmentioning

confidence: 99%

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Injection of Anti-thy-1.2 Serum Breaks Genetic Resistance of Mice against Herpes Simplex Virus

Chmielarczyk¹,

Engler²,

Ernst³

et al. 1985

Journal of General Virology

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“…[21][22][23] This humoral response in mice after HSV infection appears to parallel the response found in humans. 9,[24][25][26] There are rapid, sensitive methods for detecting anti-HSV antibodies such as ELISA (enzymelinked immunosorbent assay) and virus neutralization assay (NA). We used two strains of mice, A/J and BALB/c, to examine how prior HSV exposure and seropositivity in two different genetic backgrounds affects viral tumor therapy.…”

Section: Introductionmentioning

confidence: 99%

Effect of prior exposure to herpes simplex virus 1 on viral vector-mediated tumor therapy in immunocompetent mice

et al. 1999

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Replication-competent, attenuated mutants of herpes simrespectively. Established tumors were subsequently plex virus type 1 (HSV-1) have been shown to be effitreated intratumorally with a multi-mutated HSV-1, G207. cacious for tumor therapy. However, these studies did not G207 inhibited tumor growth to a similar extent whether address the consequences of prior exposure to HSV, as the mice were seropositive or not. We next examined the will be the case with many patients likely to receive this effect of multiple intratumoral inoculations of a 10-fold therapy. Two strains of mice, A/J and BALB/c, were lower dose of G207 on tumor growth. In the multiple treatinfected with wild-type HSV-1 by intraperitoneal injection ment group (biweekly for 3 weeks), 75% of tumors were and the immune response was determined by plaque cured, whereas no cures were seen in the single treatment reduction assay for neutralizing antibody and ELISA for group. We conclude that HSV seropositivity should not delIgG and IgM. Syngeneic tumors, N18 neuroblastoma and eteriously affect the efficacy of G207 tumor therapy, and CT26 colon carcinoma, were implanted subcutaneously in multiple inoculations of virus should be considered for HSV-1 seropositive and naive A/J and BALB/c mice, clinical evaluation.

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“…The roles of humoral versus cell-mediated immunity (CMI) in recovery from virus infection have been much debated, but it is generally held that CMI is the major mechanism in some viral infections such as herpes simplex virus (HSV) (1,2,4,7,27). The main mechanisms by which CMI in viral infection is thought to facilitate recovery are through killing of virus-infected cells nonspecifically by activated macrophages or natural killer (NK) cells, or specifically by virus-specific cytotoxic T lymphocytes (CTL).…”

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confidence: 99%

Protection of OK‐432, a Streptococcus pyogenes Preparation, against Lethal Infection of Mice with Herpes Simplex Virus

Harada

Kurokawa

Endo

et al. 1989

Microbiology and Immunology

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Experimental Infection of Inbred Mice with Herpes Simplex Virus Type 1. I. Investigation of Humoral and Cellular Immunity and of Interferon Induction

Cited by 79 publications

References 20 publications

Injection of Anti-thy-1.2 Serum Breaks Genetic Resistance of Mice against Herpes Simplex Virus

Injection of Anti-thy-1.2 Serum Breaks Genetic Resistance of Mice against Herpes Simplex Virus

Effect of prior exposure to herpes simplex virus 1 on viral vector-mediated tumor therapy in immunocompetent mice

Protection of OK‐432, a Streptococcus pyogenes Preparation, against Lethal Infection of Mice with Herpes Simplex Virus

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