Experimental infection of Opisthorchis viverrini cercariae to the cyprinid fish, Barbonymus gonionotus

Donthaisong, Chalermlap; Arunsan, Patpicha; Suwannatrai, Kulwadee; Prasopdee, Sattrachai; Kulsantiwong, Jutharat; Wongmaneeprateep, Sutee; Suwannatrai, Apiporn; Tesana, Smarn

doi:10.1016/j.actatropica.2014.04.022

Cited by 12 publications

(4 citation statements)

References 13 publications

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“…Although rainwater and irrigated water increase the chance of eggs being passively transported to a suitable habitat for the Bithynia snail intermediate hosts, other local factors, such as temperature, play an important role in snail success 29 as well as fish infection. 30 Other hydrological conditions also support disease transmission, such as low water levels and a high prevalence of infection in the snail intermediate hosts in the cool-dry season. 24 The occurrence of these seasonal transmission patterns of O. viverrini in fish has been used in the design of control options, which are then optimal in the cool-dry season.…”

Section: Transmission Of O Viverrini In Endemic Areas In Southeastmentioning

confidence: 99%

“…33,24 Experimental infection of O. viverrini cercariae in Barbonymus gonionotus showed that the ability of O. viverrini to infect fish increased with increasing age and size of fish. 30 The reason for a reduced infection in larger fish size (i.e., > 12 cm) is not clear but could be due to parasite-induced host mortality by removing large, heavily infected fish from the population. 34 The skewed (aggregated) distribution patterns of O. viverrini metacercariae in fish from Khammouane and Mukdahan provinces are typical for helminth parasites, 35 including previous records in humans.…”

Section: Transmission Of O Viverrini In Endemic Areas In Southeastmentioning

confidence: 99%

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Infection Dynamics of Opisthorchis viverrini Metacercariae in Cyprinid Fishes from Two Endemic Areas in Thailand and Lao PDR

Namsanor

Kiatsopit

Laha

et al. 2020

The American Journal of Tropical Medicine and Hygiene

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The infection dynamics of Opisthorchis viverrini metacercariae was analyzed in cyprinid fish from endemic areas in Mukdahan Province, Thailand, and Khammouane Province, Lao PDR. The fish were collected during the cool-dry (November-February), hot-dry (March-May), and rainy (June-October) seasons in 2017. They were examined by the digestion method, and the infection status was statistically analyzed by study area, season, and fish size. The prevalence (no. of fish positive/no. of fish examined × 100) and metacercarial intensities (no. of metacercariae detected/no. of fish positive) of O. viverrini in both study areas depended on season, being high in the cool-dry season and varying in the hotdry and rainy seasons. In Mukdahan Province, the average prevalence was 18.3% (range 11.0-46.7%, n = 420) and the intensity was 4.07 ± 5.86 cysts/fish (mean ± SD), whereas in Khammouane Province, the prevalence was 51.9% (range 9.1-70.6%, n = 673) and the intensity was 6.67 ± 12.88 cysts/fish. Among the cyprinid fish species examined, the infection was associated with fish body size and predominantly found in Hampala dispar (86.5%), Cyclocheilichthys armatus (73.2%), and Puntius brevis (42.7%). The distribution of O. viverrini metacercariae in fish was skewed, with most of the fish having a low worm burden with an average of four to six cysts/fish. The findings that seasonality, sampling locality, fish size, and species of fish play roles in the risk of O. viverrini infection imply that these host and environmental factors are important for the transmission dynamics and control of O. viverrini.

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Section: Transmission Of O Viverrini In Endemic Areas In Southeastmentioning

confidence: 99%

Section: Transmission Of O Viverrini In Endemic Areas In Southeastmentioning

confidence: 99%

Infection Dynamics of Opisthorchis viverrini Metacercariae in Cyprinid Fishes from Two Endemic Areas in Thailand and Lao PDR

Namsanor

Kiatsopit

Laha

et al. 2020

The American Journal of Tropical Medicine and Hygiene

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“… 10 – 12 The fish accumulate infectious metacercariae, particularly in the head and fin regions, and have a much higher prevalence of infection, ranging from 42.9% (in Henicorhynchus lineatus ) to 100% (in Amblyrhynchichthys truncates ). 13 Humans may become infected when they eat infected cyprinid fish without heating the flesh sufficiently in raw, partially cooked, or fermented dishes such as Koi Pla . 14 , 15 Dishes such as this are socially and culturally significant, making the encouragement of changes to eating patterns challenging.…”

Section: Biology Of Opisthorchis Viverrinimentioning

confidence: 99%

Opisthorchiasis and cholangiocarcinoma in Southeast Asia: an unresolved problem

Hughes

O’Connor

Techasen³

et al. 2017

IJGM

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The prevalence of cholangiocarcinoma (CCA) in Southeast Asia is much higher than other areas of the world. Eating raw, fermented, or undercooked cyprinid fish, infected with the liver fluke, Opisthorchis viverrini sensu lato (sl), results in chronic biliary inflammation, periductal fibrosis, and increased cancer risk. There may be associated glomerulonephritis. The process of infection is difficult to disrupt because eating practices have proven extremely difficult to change, and the life cycle of the fluke cannot be broken due to high prevalence in canine and feline reservoir hosts. Fecal analysis and enzyme-linked immunosorbent assay tests can be used to diagnose opisthorchiasis. Diagnosis of CCA is complex, partly due to the lack of definitive imaging characteristics but also due to the difficulty of obtaining samples for cytology or histology. This cancer has proven to be resistant to common chemotherapy treatments and so the two avenues of treatment available are surgical resection and liver transplantation, both requiring early detection of the tumor for the best chances of success. Late presentation of symptoms reduces the chances of successful surgical intervention. While liver fluke infections can be treated with praziquantel, individuals will often become reinfected, and multiple reinfections can be more harmful than a singular, long-term infection. A key research on the detection and characterization of novel biomarkers in all parts of the carcinogenic pathway for early diagnosis is needed.

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“…In Thailand at least 6 million people are estimated to be currently infected (Andrews et al, 2008). Opisthorchis viverrini infection in humans and in dog and cat host reservoirs (Sithithaworn & Haswell-Elkins, 2003) occurs via the consumption of a raw or uncooked fi sh which contains infective metacercariae (Sripa et al, 2007;Donthaisong et al, 2014;Madsen et al, 2015;Onsurathum et al, 2016) In addition, fermented fi sh also contain high concentrations of nitrosamines that are known to be potent human carcinogens (Thamavit et al, 1993). Once metacercariae are ingested they migrate to the intrahepatic bile duct via the common bile duct and once the fl uke becomes gravid (in about 30 days) the eggs are excreted by feces .…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of Opisthorchis viverrini in an endemic area of Thailand, an integrative approach

et al. 2017

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SummaryAn integrated epidemiological study of Opisthorchis viverrini consisting of risk factors analysis and parasitation prevalence determination in humans, as well as the assessment the roles of host reservoirs (dogs and cats) and intermediate hosts (cyprinid fi sh) was carried out in the vicinity of Huay Luang dam, Udon Thani province, in the north east of Thailand. The survey was conducted from June 2014 to July 2016 in three sub-districts. Fecal samples were collected from 5,347 participants in 22 villages and the overall prevalence of O. viverrini was found to be 31.5 %. Risk factors for liver fl uke infection were determined from questionnaires analysis which sought demographic data and information about the eating behaviors of the participants. The behavior of raw fi sh consumption correlated signifi cantly with parasitation in the studied areas. The risk factors for O. viverrini infection in humans were associated signifi cantly with age, education, and habitation within a two kilometer range from nearby water and food sources. Questionnaires showed that the drug treatments were not always appropriate. The stools of domestic dogs (n = 468) and cats (n = 262) collected for parasitological analysis and results showed that the zoonotic role of dogs should not be underestimated as has been done previously/in past. The incidence of O. viverrini metacercariae in four cyprinid fi shes Barbonymus gonionotus (n = 124), Cyclocheilichthys repasson (n = 843), Hampala dispar (n = 276) and Henicorhynchus siamensis n = 946), were determined and overall values ranged from 2.4 % to 23.1 %. There was a seasonal variation in metacercariae intensity which ranged from 1 -125 metacercariae per fi sh. The study concluded that transmission ecology should be taken into consideration in developing of control strategies against opisthorchiasis.

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Experimental infection of Opisthorchis viverrini cercariae to the cyprinid fish, Barbonymus gonionotus

Cited by 12 publications

References 13 publications

Infection Dynamics of Opisthorchis viverrini Metacercariae in Cyprinid Fishes from Two Endemic Areas in Thailand and Lao PDR

Infection Dynamics of Opisthorchis viverrini Metacercariae in Cyprinid Fishes from Two Endemic Areas in Thailand and Lao PDR

Opisthorchiasis and cholangiocarcinoma in Southeast Asia: an unresolved problem

Epidemiology of Opisthorchis viverrini in an endemic area of Thailand, an integrative approach

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