1963
DOI: 10.1001/archneur.1963.00460120036004
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Experimental Intracerebral Hematoma

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Cited by 19 publications
(12 citation statements)
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“…4 More recently, investigators showed that the intracerebral injection of 0.05-0.25 ml autologous blood into the brains of cats reduced cerebral blood flow in the tissue around the hematoma.…”
Section: Discussionmentioning
confidence: 99%
“…4 More recently, investigators showed that the intracerebral injection of 0.05-0.25 ml autologous blood into the brains of cats reduced cerebral blood flow in the tissue around the hematoma.…”
Section: Discussionmentioning
confidence: 99%
“…In two other CT studies after spontaneous ICH, the authors did not mention the sites of the residual lesions. 6 - 10 The appearance of slit-like lesions after a hemorrhage in the basal ganglia, as shown in a study on experimental ICH, 11 probably results more from the splitting of nerve fibers by the hemorrhage than from destruction of nerve fibers. 12 Perhaps this also explains the absence of any type of residual lesion in seven of our 42 patients (17%), a proportion that agrees with two previous studies.…”
Section: Discussionmentioning
confidence: 95%
“…On histological examination, it is easy to detect old hemorrhagic lesions with a staining reaction for iron. 11 The pathological-anatomic features of such residual lesions after ICH may consist of "slits" (cleft-shaped collapsed cavities) or cysts, which are often filled with fluid and are sometimes connected to the ventricular system. 15 A large and isolated hypodense area in a cerebral lobe might resemble a low-grade astrocytoma.…”
Section: Discussionmentioning
confidence: 99%
“…The first is the intracerebral injection of autologous blood. Initially developed in the 1960s (31), this model has been used in both large animals (3234) (with injections typically performed into the frontal lobe) and rodents (15, 35) (with injections typically performed into the basal ganglia). This model has the advantage of allowing for control of hemorrhage volume but does not mimic the effects of vessel rupture seen in SICH (36).…”
Section: Animal Modelsmentioning
confidence: 99%