Experimental Intracranial Aspergillosis

NeosporaAbortion Storm in a Midwestern Dairy

“…In this report, causes of abortion in dairy cattle. 1,2,[5][6][7] Neospora infection is we describe a Neospora abortion storm in a dairy herd of a particularly serious problem in the large dairies of the West moderate size in South Dakota. Coast and Southwest.…”

“…This report illustrates the emerging importance of this disease in areas other than the West Coast and Southwest. Because Neospora has been reported from every region of the United States, 5,6 it should be included on the list of agents capable of causing abortion storms in dairy cattle irrespective of the geographic location of the herd.…”

Listeria monocytogenesencephalitis associated with corticosteroid therapy

“…Thereason for this effect of corticosteroids is not known but various possibilities have been reviewed by Simpson et al (1967). Corticosteroids increase the infectivity of Aspergillus flavus in mice, and Epstein, Verney, Miale, and Sidransky (1967) suggested that this was due to stabilization of lysosomal membranes within the macrophages by the steroids, preventing the release of catabolic enzymes and destruction of the fungus. A similar mechanism might account for the reduced resistance to listerial infection in animals and man on steroid therapy, and for the poor response to antibiotics and survival of living bacteria.…”

Endocarditis and Pulmonary Aspergillosis in a Horse

“…is also common in humans and does not always indicate invasion; however, in certain subgroups such as immunocompromised patients the isolation suggestive of invasion 11,20 ofAspergillus spp. is highly Although the pathogenesis of invasive pulmonary or systemic aspergillosis is not known, certain factors such as use of immunosuppressive drugs, chronic antibiotic therapy, and systemic diseases do predispose humans 5,17 and horses 3,12,13,19 to pulmonary infections. There is also a recent report of Aspergillus-induced granuloma formation in the mediastinum of a nonimmunocompromised horse.…”