Experimental investigation and modelling of closed-loop recycling in preparative chromatography

Heuer, Christian; Seidel‐Morgenstern, A.; Hugo, P.

doi:10.1016/0009-2509(94)00498-g

Cited by 51 publications

(21 citation statements)

References 16 publications

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“…For preparative purposes, the recycling methods provide a more cost-effective solution than, e.g., simulated moving-bed methods [28] since existing columns and equipment can be used. Theoretical analyses of both analytical [27] and preparative [29,30] recycling methods have appeared. In this paper, we will limit our theoretical treatment to analytical recycling chromatography.…”

Section: Liquid Chromatographymentioning

confidence: 99%

Cyclic electrophoretic and chromatographic separation methods

2004

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A review is given of the application of cyclic analytical methods in capillary electroseparation (CE) and liquid chromatography (LC) systems. Cyclic methods have been used since the early sixties in chromatographic systems to overcome pressure limitations to resolution. From the early nineties on they have also been applied in capillary electroseparation systems to overcome voltage limitations. Some basic theory is given, outlining the temporal development of resolution in cyclic CE and LC systems and calculating the maximal resolution that can be obtained as a function of the operational parameters of pressure and electrical field. Simple equations are given for the temporal change in the peak capacity and the loss of peaks from the systems as it occurs in some cyclic systems. Finally, a circular open tubular chromatographic system is proposed using integrated pumping and continuous detection. The performance of such a system is discussed using magnetohydrodynamic and alternating current electroosmotic pumping as examples of integrated pumps and Shah Convolution Fourier transform detection as an example of a continuous detection method.

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Section: Liquid Chromatographymentioning

confidence: 99%

Cyclic electrophoretic and chromatographic separation methods

2004

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“…Recycling chromatography is characterized by the fact that the sample to be separated is transported several times through the column. Thus, a longer column is simulated [5], leading to an improved separation until the point when the sample is spread over the whole column and subsequent cycles begin to overlap. To postpone this effect and to reach higher yields, the possibility to take in each cycle sufficiently purified fractions out of the recycle loop (peak shaving) exists.…”

Section: Process Engineering Conceptsmentioning

confidence: 99%

Comparison of Various Process Engineering Concepts of Preparative Chromatography

Heuer¹,

Kniep²,

Falk

et al. 1998

Chem. Eng. Technol.

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Liquid chromatography utilizing porous solid phases (adsorption chromatography) is one of the most powerful and versatile methods of modern analytical chemistry. Its widespread application is due in part to the development of a broad range of combinations of solid stationary and liquid mobile phases. Normal phase and reverse phase chromatography with pure and chemically modified silica, respectively, affinity chromatography, can be cited as examples [1]. In addition to its use as an analytical method, chromatography is becoming increasingly important in the preparative scale for the isolation of pure substances in the pharmaceutical industry, in biotechnology, and in the production of fine chemicals. In many cases, the required purity criteria can only be met with chromatographic techniques, as in the resolution of racemates. From a process engineering viewpoint, a better understanding of concentration profile deformations caused by intended overloading of separation columns has recently been acquired [2]. In particular, this concerns the description of displacement and entrainment effects associated with the competitive adsorption. A series of alternative operating modes has been developed and used [3] to enhance yields and productivities. In spite of a number of attempted comparative studies [4], quantitative information about optimizing these processes is lacking. This article will compare four different process engineering concepts of preparative chromatography on the basis of a uniform theoretical model.

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“…Recycle chromatography allows a sample to be passed over a column several times without the need for a long column or reinjection of the sample (Wankat, 1986). This results in a high-resolution, increased efficiency and low-pressure drop (Nakamura et al, 1973;Martin et al, 1976;Bailly and Tondeur, 1982;Seidel-Morgenstern and Guiochon, 1993;Heuer et al, 1995). Basically, there are two recycle strategies: closed-loop (Bombaugh et al, 1969;Biesenberger et al, 1971) and alternative pumping recycle .…”

mentioning

confidence: 97%

Recovery and purification of paclitaxel using low‐pressure liquid chromatography

et al. 1997

AIChE Journal

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Experimental investigation and modelling of closed-loop recycling in preparative chromatography

Cited by 51 publications

References 16 publications

Cyclic electrophoretic and chromatographic separation methods

Cyclic electrophoretic and chromatographic separation methods

Comparison of Various Process Engineering Concepts of Preparative Chromatography

Recovery and purification of paclitaxel using low‐pressure liquid chromatography

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