Experimental investigations were conducted to explore the thermal and exergy efficiency of Fe 3 O 4-H 2 O nanofluids in a corrugated tube. Some influences of the twisted turbulator, horizontal magnetic fields (B = 6mT, 12mT, and 18mT), particle mass fractions (ω = 0.1, 0.3, and 0.5 wt%) as well as Re numbers (800-12,000) were analyzed. The experimental results exhibited that the heat transfer capacity of nanofluids intensifies with the increment of mass fraction but weakens with the increase of magnetic flux density. For the same external conditions, the heat transfer capability of the corrugated tube with an inserted twisted turbulator is obviously stronger than that without the turbulator. The resistance coefficient can be augmented by the increasing mass fraction and horizontal magnetic field. In addition, the thermal efficiency R3 and the exergy efficiency were adopted to estimate the comprehensive performance of each working condition. It could be found that the increased mass fraction and reduced magnetic flux density cause an increasing trend on the thermal efficiency. Also, it was obtained that the exergy efficiency of working fluids is intensified under identical pumping power.