Experimental Investigation of &lt;sup&gt;99m&lt;/sup&gt;Тс-Nanotech Used for Lymph Nodes Visualization

Синилкин, И. Г.; Чернов, В. И.; Titskaya, Anna; Zelchan, Roman; Daneikina, N.V.

doi:10.4028/www.scientific.net/amr.1084.389

Cited by 1 publication

(3 citation statements)

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“…Their applications are limited by their complex manufacturing process and high cost. Furthermore, the extremely low accumulation of these radiopharmaceuticals in SLNs may lead to further redistribution of a radiotracer through the lymphatic collector and an erroneous interpretation of the results [6,10].…”

Section: Introductionmentioning

confidence: 99%

“…Clinically, radioactive nanocolloids have been used for investigations of lymphatic drainage, and recently, more specifically for identification of the sentinel node in investigations of metastatic spread of some cancers [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…During passage through the lymphatic system, nanoparticles lose their organic coating and persistent uptake in SLN without redistribution in the body. In addition, 99m Tc-Al 2 O 3 has an optimum nanoparticle size from 50 to 100 nm, whereby the tracer quickly leaves the injection site and migrates through the lymphatic system [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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The first experience of using 99mTc-Al2O3-based radiopharmaceutical for the detection of sentinel lymph nodes in cervical cancer patients

Синилкин¹,

Chernov²,

Lyapunov

et al. 2016

AIP Conference Proceedings

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Abstract. The purpose of the study was to evaluate the feasibility of using 99m Tc-Al 2 O 3 -based radiopharmaceutical, a novel molecular imaging agent for sentinel lymph node detection in patients with invasive cervical cancer. The study included 23 cervical cancer patients (T1aN M -T2bN M ) treated at the Tomsk Cancer Research Institute. In the 18 hours before surgery, 80 MBq of the 99m Tc-Al 2 O 3 in peritumoral injected, followed by single-photon emission computed tomography (SPECT) of the pelvis and intraoperative SLN identification. Twenty-seven SLNs were detected by SPECT, and 34 SLNs were identified by intraoperative gamma probe. The total number of identified SLNs per patient ranged from 1 to 3 (the mean number of SLNs was 1.4 per patient). The most common site for SLN detection was the external iliac region (57.2%), followed by the internal iliac (14%), obturator (14%), presacral and retrosacral regions (14%), and the parametrial region (1%). Sensitivity in detecting SLNs was 100% for intraoperative SLN identification and 79% for SPECT image.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%