Self-piercing riveting was adopted to join high impact polystyrene (HIPS) and metal sheets which had huge difference in material properties. Three kinds of metal sheet (AA1060, AA5052, and HC340LA) were joined to HIPS sheet. The effect of polymer sheet thickness on mechanical properties of joints was investigated. The static loads of joints were measured in tensile and shearing tests. The failure modes of joints were analyzed. The cross sections of joints were observed by metallographic microscope. Results showed that self-piercing riveting could effectively join HIPS and metal sheets when polymer sheet was placed as top sheet. All joints failed in the manner of polymer fracture in both tensile and shearing tests. For joints with different sheet material combinations, though the cross sections and geometrical parameters of joints had great difference, the static loads and absorbed energy values of joints were nearly the same. When AA5052 sheets were joined to HIPS sheets with different thickness values, with the increase of polymer sheet thickness, the flaring degree of rivet decreased, while static loads and absorbed energy values of joints increased. This was because the strength of interlock structure was higher than that of polymer sheet and the strength of joint was determined by the strength of polymer sheet.