This investigation delineates the impact of pozzolanic constituents and industrial byproducts on the mechanical properties of self-compacting concrete (SCC). Calcined kaolinitic clay (CKC), waste marble powder (WMP), and limestone powder (LP) were utilized as cementitious supplements in various binary, ternary, and quaternary formulations. Specimens were synthesized by varying the substitution ratios of CKC, WMP, and LP within the cement matrix. The fresh state characteristics, encompassing L-Box height ratio, segregation resistance, V-funnel flow time, and slump flow diameter, were quantitatively assessed. Concurrently, the hardened state properties were examined at 7, 28, and 56-day maturation periods. Results demonstrated that the optimal binary blend, containing 10% WMP and 10% LP, significantly augmented the fresh properties and compressive strength of SCC. Ternary mix compositions further enhanced both compressive and tensile strengths, as well as ultrasonic pulse velocity, with peak values reaching 57.8 MPa, 4.61 MPa, and 4670 m/s, respectively, thereby surpassing traditional mortar benchmarks. The study's findings substantiate the potential of integrating CKC, WMP, and LP to not only bolster the performance of SCC but also to curtail cement usage, thereby reducing associated CO2 emissions and enhancing sustainability. This research offers a compelling narrative for the construction sector, advocating for the adoption of alternative materials in the production of advanced, high-performance selfcompacting concrete.