Experimental investigation on penetration performance of larger volume needle-free injection device

Zeng, Deliang; Wu, Ni; Lei, Qian; Shi, Hao; Kang, Yong

doi:10.1007/s12206-020-0840-x

Cited by 11 publications

(3 citation statements)

References 37 publications

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“…Although the average volume of ejected HA corresponded well with the volume indicated by the manufacturers (91.5-97.6 and 100 mL, respectively), the volume of HA delivered into the skin was negligible, which was confirmed by 3D visualization. This low injection efficiency may be related to differences in driving pressure and nozzle diameter, 17,18 leading to slower jet speeds compared with the medical jet injectors. Another factor that may play a role is the relatively high viscosity of HA, making jet injection more challenging in general.…”

Section: Discussionmentioning

confidence: 99%

Home-Use Hyaluronic Acid Jet Injectors: Unreliable and Unsafe

Juch,

Bik,

Boeijink

et al. 2023

Dermatol Surg

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BACKGROUND Needle-free hyaluronic acid (HA) jet injectors are gaining popularity for rejuvenation treatment. The devices are widely available online and are used for self-injection or in beauty salons by nonphysicians. However, little is known about their performance and safety. OBJECTIVE To explore the injection efficiency and cutaneous biodistribution patterns administered with home-use compared with medical jet injectors and to assess safety aspects. MATERIALS AND METHODS The authors injected HA into ex vivo human skin with 4 home-use and 2 medical injectors. The intracutaneous dose of HA was calculated, and the cutaneous biodistribution of HA was assessed using a 3-dimensional Fluorescent Imaging Cryomicrotome System (3D-FICS). Safety aspects were evaluated based on the presence of a manual, CE (conformité européenne) mark, and sterility. RESULTS The intracutaneous dose delivered by the home-use injectors was markedly lower compared with the medical injectors. 3D imaging for home-use injectors showed superficial epidermal distribution with low distribution volumes. For medical injectors, volumes were substantially larger and mainly middermal. All evaluated safety aspects were lacking. CONCLUSION Results of this study suggest that the specific combinations of home-use injectors and HA used in this study are unreliable and unsafe, which casts doubts on the performance of these treatments in general.

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Section: Discussionmentioning

confidence: 99%

Home-Use Hyaluronic Acid Jet Injectors: Unreliable and Unsafe

Juch,

Bik,

Boeijink

et al. 2023

Dermatol Surg

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“…Based upon the actuation type used for the displacement of the piston, they are usually classified as mechanically driven or electrically driven injectors [ 4 ]. A compressed spring [ 5 – 13 ] or an expanding gas or air [ 14 – 21 ] is used as the energy sources for mechanical actuators, whereas electrical actuators use the Lorentz force [ 22 – 29 ] or piezoelectric energy [ 30 , 31 ] to pressurize the injection fluid to obtain high-velocity microjets. These propelled microjets have velocities of approximately 100 m/s, which may be sufficient to penetrate the skin surface (reported to be around 15 MPa [ 32 ]) and deliver the drug to a particular depth in the skin tissue.…”

Section: Introductionmentioning

confidence: 99%

Dynamic interaction of injected liquid jet with skin layer interfaces revealed by microsecond imaging of optically cleared ex vivo skin tissue model

et al. 2023

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Background Needle-free jet injection (NFJI) systems enable a controlled and targeted delivery of drugs into skin tissue. However, a scarce understanding of their underlying mechanisms has been a major deterrent to the development of an efficient system. Primarily, the lack of a suitable visualization technique that could capture the dynamics of the injected fluid–tissue interaction with a microsecond range temporal resolution has emerged as a main limitation. A conventional needle-free injection system may inject the fluids within a few milliseconds and may need a temporal resolution in the microsecond range for obtaining the required images. However, the presently available imaging techniques for skin tissue visualization fail to achieve these required spatial and temporal resolutions. Previous studies on injected fluid–tissue interaction dynamics were conducted using in vitro media with a stiffness similar to that of skin tissue. However, these media are poor substitutes for real skin tissue, and the need for an imaging technique having ex vivo or in vivo imaging capability has been echoed in the previous reports. Methods A near-infrared imaging technique that utilizes the optical absorption and fluorescence emission of indocyanine green dye, coupled with a tissue clearing technique, was developed for visualizing a NFJI in an ex vivo porcine skin tissue. Results The optimal imaging conditions obtained by considering the optical properties of the developed system and mechanical properties of the cleared ex vivo samples are presented. Crucial information on the dynamic interaction of the injected liquid jet with the ex vivo skin tissue layers and their interfaces could be obtained. Conclusions The reported technique can be instrumental for understanding the injection mechanism and for the development of an efficient transdermal NFJI system as well.

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“…As a result of recent research there have been advances in the laser ablation of skin, passive medication absorption, iontophoresis using electric charges for enhanced drug delivery [46], electroporation for pore formation in the stratum corneum to eliminate the skin barrier [47][48][49], sonophoretic drug delivery using ultrasonic waves, microneedles of different shapes and sizes [50], and powder and liquid jet injections [51][52][53]. This article investigates the intradermal routes of inoculation and is focused on liquid jet injections [12][13][14]54]. All the routes, as mentioned earlier, involve breaking the skin barrier (which is made up of about 30 layers of dead skin cells and is known as the stratum corneum) by either degrading it or by piercing it in various ways.…”

Section: Introductionmentioning

confidence: 99%

A Needle-Free Jet Injection System for Controlled Release and Repeated Biopharmaceutical Delivery

Trimzi

Ham

2021

Pharmaceutics

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Swift vaccination is necessary as a response to disease outbreaks and pandemics; otherwise, the species under attack is at risk of a high fatality rate or even mass extinction. Statistics suggest that at least 16 billion injections are administered worldwide every year. Such a high rate of needle/syringe injection administration worldwide is alarming due to the risk of needle-stick injuries, disease spread due to cross-contamination and the reuse of needles, and the misuse of needles. In addition, there are production, handling, and disposal costs. Needle phobia is an additional issue faced by many recipients of injections with needles. In addition to a detailed literature review highlighting the need for needle-free injection systems, a compressed air-driven needle-free jet injection system with a hydro-pneumatic mechanism was designed and developed by employing an axiomatic design approach. The proposed injection system has higher flexibility, uninterrupted force generation, and provides the possibility of delivering repeated injections at different tissue depths from the dermis to the muscle (depending on the drug delivery requirements) by controlling the inlet compressed air pressure. The designed needle-free jet injector consists of two primary circuits: the pneumatic and the hydraulic circuit. The pneumatic circuit is responsible for driving, pressurizing, and repeatability. The hydraulic circuit precisely injects and contains the liquid jet, allowing us to control the volume of the liquid jet at elevated pressure by offering flexibility in the dose volume per injection. Finally, in this paper we report on the successful design and working model of an air-driven needle-free jet injector for 0.2–0.5 mL drug delivery by ex vivo experimental validation.

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Experimental investigation on penetration performance of larger volume needle-free injection device

Cited by 11 publications

References 37 publications

Home-Use Hyaluronic Acid Jet Injectors: Unreliable and Unsafe

Home-Use Hyaluronic Acid Jet Injectors: Unreliable and Unsafe

Dynamic interaction of injected liquid jet with skin layer interfaces revealed by microsecond imaging of optically cleared ex vivo skin tissue model

A Needle-Free Jet Injection System for Controlled Release and Repeated Biopharmaceutical Delivery

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