Experimental Investigation on the Influence of Target Physical Properties on an Impinging Plasma Jet

Simoncelli, Emanuele; Stancampiano, Augusto; Boselli, Marco; Gherardi, Matteo; Colombo, Vittorio

doi:10.3390/plasma2030029

Cited by 25 publications

(17 citation statements)

References 23 publications

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“…It has been reported that the surface of treatment can greatly affect plasma discharge. [13,28] Lin et al [13] and Simoncelli et al [28] have shown that electrical power is higher for plasma discharges on metal compared to a dielectric for both DBDs and plasma jets, respectively. As plasma treatments in this study for all chemical and biological analyses were performed in polystyrene well plates, the energy per pulse of DBD plasma was calculated in a setting that closely resembles these experiments (Figure 1).…”

Section: Discussionmentioning

confidence: 99%

Toward defining plasma treatment dose: The role of plasma treatment energy of pulsed‐dielectric barrier discharge in dictating in vitro biological responses

Lin

Biscop

Gorbanev

et al. 2021

Plasma Processes & Polymers

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The energy dependence of a pulsed-dielectric barrier discharge (DBD) plasma treatment on chemical species production and biological responses was investigated. We hypothesized that the total plasma energy delivered during treatment encompasses the influence of major application parameters. A microsecond-pulsed DBD system was used to treat three different cancer cell lines and cell viability was analyzed. The energy per pulse was measured and the total plasma treatment energy was controlled by adjust-

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Section: Discussionmentioning

confidence: 99%

Toward defining plasma treatment dose: The role of plasma treatment energy of pulsed‐dielectric barrier discharge in dictating in vitro biological responses

Lin

Biscop

Gorbanev

et al. 2021

Plasma Processes & Polymers

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“…A comprehensive discussion on these topics can be found in 13 – 16 . The influence of the target characteristics on the plasma behaviour is most easily observed through fast imaging of the discharge and gas flow visualization 17 . To understand the electron dynamics more advanced diagnostics are required.…”

Section: Introductionmentioning

confidence: 99%

Impact of electrical grounding conditions on plasma–liquid interactions using Thomson scattering on a pulsed argon jet

Slikboer

Walsh

2021

Sci Rep

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The interaction between an argon plasma jet excited using microsecond duration voltage pulses and a liquid target was examined using Thomson scattering to quantify the temporal evolution of the electron density and temperature. The electrical resistance between a liquid target and the electrical ground was varied from 1 to $$680\, \text {k}\Omega $$ 680 k Ω to mimic different conductivity liquids while the influence of the varying electrical properties on the electron dynamics within the plasma were examined. It was demonstrated that the interaction between the plasma jet and a liquid target grounded via a high resistance resulted in typical dielectric barrier discharge behaviour, with two discharge events per applied voltage pulse. Under such conditions, the electron density and temperature reached a peak of $$1\cdot 10^{15}\, \text {cm}^{-3}$$ 1 · 10 15 cm - 3 and 3.4 eV, respectively; with both rapidly decaying over several hundreds of nanoseconds. For liquid targets grounded via a low resistance, the jet behaviour transitioned to a DC-like discharge, with a single breakdown event being observed and sustained throughout the duration of each applied voltage pulse. Under such conditions, electron densities of $$2{-}3 \cdot 10^{15}\, \text {cm}^{-3}$$ 2 - 3 · 10 15 cm - 3 were detected for several microseconds. The results demonstrate that the electron dynamics in a pulsed argon plasma jet are extremely sensitive to the electrical characteristics of the target, which in the case of water, can evolve during exposure to the plasma.

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“…As the plasma-liquid chemistry is of less importance, also short-lived species such as superoxide and hydroxyl radicals, that would rapidly deteriorate under in vitro culture conditions before reaching the cells, have to be taken into account 46 . Other parameters, such as electric fields, investigated as a mechanism contributing to plasma medicine effects [90][91][92] , might also be considered to explain the differences.…”

Section: Discussionmentioning

confidence: 99%

Tumor cytotoxicity and immunogenicity of a novel V-jet neon plasma source compared to the kINPen

Miebach

Freund

Horn

et al. 2021

Sci Rep

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Recent research indicated the potential of cold physical plasma in cancer therapy. The plethora of plasma-derived reactive oxygen and nitrogen species (ROS/RNS) mediate diverse antitumor effects after eliciting oxidative stress in cancer cells. We aimed at exploiting this principle using a newly designed dual-jet neon plasma source (Vjet) to treat colorectal cancer cells. A treatment time-dependent ROS/RNS generation induced oxidation, growth retardation, and cell death within 3D tumor spheroids were found. In TUM-CAM, a semi in vivo model, the Vjet markedly reduced vascularized tumors' growth, but an increase of tumor cell immunogenicity or uptake by dendritic cells was not observed. By comparison, the argon-driven single jet kINPen, known to mediate anticancer effects in vitro, in vivo, and in patients, generated less ROS/RNS and terminal cell death in spheroids. In the TUM-CAM model, however, the kINPen was equivalently effective and induced a stronger expression of immunogenic cancer cell death (ICD) markers, leading to increased phagocytosis of kINPen but not Vjet plasma-treated tumor cells by dendritic cells. Moreover, the Vjet was characterized according to the requirements of the DIN-SPEC 91315. Our results highlight the plasma device-specific action on cancer cells for evaluating optimal discharges for plasma cancer treatment.

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Experimental Investigation on the Influence of Target Physical Properties on an Impinging Plasma Jet

Cited by 25 publications

References 23 publications

Toward defining plasma treatment dose: The role of plasma treatment energy of pulsed‐dielectric barrier discharge in dictating in vitro biological responses

Toward defining plasma treatment dose: The role of plasma treatment energy of pulsed‐dielectric barrier discharge in dictating in vitro biological responses

Impact of electrical grounding conditions on plasma–liquid interactions using Thomson scattering on a pulsed argon jet

Tumor cytotoxicity and immunogenicity of a novel V-jet neon plasma source compared to the kINPen

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