Experimental Lathyrism in Mice Fed Diets Containing Sweet Peas or  -aminopropionitrile.

Dasler, Waldemar; Milliser, Russell V.

doi:10.3181/00379727-96-23422

Cited by 14 publications

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EXPERIMENTAL lathyrism means the syndrome produced in experimental animals given sweet-pea seeds, their active principle /I-aminopropionitrile (BAPN), or one of a number of other related and unrelated chemicals. The early work has been reviewed by Selye (1957); since then important developments have been the demonstration by Dasler (1958) that semicarbazide has a lathyrogenic effect, and the recent discoveries that there is a failure in intramolecular (Martin et aZ., 1961, 1963) and intermolecular (Gross, 1963) linking in the collagen of lathyric rats.Most workers on experimental lathyrism have used rats, but, since the demonstration that mice also are susceptible (Dasler and Milliser, 1957;McCallum, 1958), its cheapness and ease of handling have made the mouse the experimental animal of choice for many types of investigation. The present paper describes the effects of lathyrogenic agents in mice with special reference to the vascular lesions, and deduces that the cause of the aortic rupture is a failure in formation of the elastic laminae.

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“…Most workers on experimental lathyrism have used rats, but, since the demonstration that mice also are susceptible (Dasler and Milliser, 1957;McCallum, 1958), its cheapness and ease of handling have made the mouse the experimental animal of choice for many types of investigation. The present paper describes the effects of lathyrogenic agents in mice with special reference to the vascular lesions, and deduces that the cause of the aortic rupture is a failure in formation of the elastic laminae.…”

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Experimental lathyrism in mice

1965

J. Pathol.

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Experimental lathyrism in mice

1965

J. Pathol.

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“…One luiiidred and sixty 2S day old inale alb iiio miee I'rom Ihe Waitc AgricuUural Research Institute of the Uiiivei'sity of Adelaide were selected at ratuloiii aiul divided iiito two equal gi'oups. The expei'iiiieiital group was led, (td lihiltttit, a lathyritic diet cotnprising equal parts of grouiid sweel pea seeds (Ldlliyrtts odoratus) and a proprietary bruiid ol iiiousc cubes (Dasler & Milliser 1957, McCallufiT 1958. Cotilrol aiiiinals weic led gi'OLiiul iiiouse cubes ttd lihitiint.…”

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confidence: 99%

Oxytalan fibre response to tooth intrusion and extrusion in normal and lathyritic mice

Sims

1978

J of Periodontal Research

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Springs were applied to the mandibles of normal mice to produce intrusion of one first molar and extrusion of the opposite first molar. Treatments were randomly allocated to the right and left sides of the jaw. The experiment was repeated in lathyritic mice. Hostologic sections demonstrated that major oxytalan fibres underwent marked changes in their angle of attachment to the cementum when comparing an intruded tooth with its extruded counterpart in either normal or lathyritic animals. A sample of 10 angular readings was tken from each tooth. A mixed model analysis of variance showed a significant difference at the 1% level in the angle attributed to the type of treatment applied. The data lend support to the hypothesis that oxytalan fibres are capable of independent function within the normal and also the pathologically affected periodontal ligament of mice.

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“…The sample was restricted to males as McCallum (1965) reported that histological findings differ slightly between males and females. The animals were 28-days-old and had an average weight of 29 g. The experimental group was fed ad libitum a finely ground mixture comprising equal parts of crushed sweet pea seeds and a proprietary brand of mouse cubes (Dasler & Milliser 1957). The control group was fed finely ground mouse cubes ad libitum.…”

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confidence: 99%

The Oxytalan Fiber System in the Mandibular Periodontal Ligament of the Lathyritic Mouse

Sims

1977

J Oral Pathology Medicine

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Experimental lathyrism was produced in young albino mice with a diet containing 50 % sweet pea seed (Lathyrus odoratiis). After 7 days on the lathyritic diet, sections of the mandibular molar and incisor periodontal ligaments, when oxidized and treated wi(h aldehyde fuchsin, demonstrated enhanced staining of the oxytalan fibers and numerous vessels. At this time aldehyde fuchsin or orcein also revealed marked pathological changes in (he periodontal ligament of all molars. When lathyrism was prolonged for 12 weeks, both the molar and incisor oxytalan systems were still readily identifiable although the molar periodontal ligament continued to be severely affected by lathyrism. The oxytalan fibers retained their characteristic tooth-vascular association in all of the lathyritic mice. Oxytalan fibers of the lathyritic and control animals showed similar reactions to enzyme digestion with beta-glucuronidase, elastase, and pepsin. However, gingival elastic fibers reacted in a different way from oxytalan fibers with beta-glucuronidase and elastase treatment. These findings indicate that in (he lathyritic mouse the oxytalan fiber system of functioning teeth possesses a high degree of permanence and is metabolically distinct from collagen and elastic fibers.

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Experimental Lathyrism in Mice Fed Diets Containing Sweet Peas or -aminopropionitrile.

Cited by 14 publications

References 1 publication

Experimental lathyrism in mice

Experimental lathyrism in mice

Oxytalan fibre response to tooth intrusion and extrusion in normal and lathyritic mice

The Oxytalan Fiber System in the Mandibular Periodontal Ligament of the Lathyritic Mouse

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