Experimental lathyrism in mice

Hm, Mccallum

doi:10.1002/path.1700890223

Cited by 19 publications

(15 citation statements)

References 12 publications

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“…The effect of BAPN on the older rats of this study agrees with the results of earlier workers (1,(3)(4)(5)(6)(7) but is in contrast to the results reported by Schmidt and Orbison (11) who found that on a mg of BAPN/g of body weight basis, exostoses de-velop as rapidly and extensively in adult rats as in weanlings. Perhaps the difference in route of administration of BAPN affects the results, as it was given by mouth in one case and by intraperitoneal injection in the other.…”

contrasting

confidence: 52%

“…2 USPHS Career Development awardee, 5K3 AM 7876. entirely to an increase in nondiffusible calcium, with little or no change in ionized or ultrafilterable calcium (5-7). Clegg et d. (7) using electrophoretic techniques, and Urist et QZ. (6) using ultracentrifugation, presented evidence that the nondiffusible serum component which binds calcium in laying hens or estrogenized roosters is a phosphoruscontaining protein.…”

mentioning

confidence: 98%

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Lathyrism and Aging

Yeager¹

1968

Experimental Biology and Medicine

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confidence: 52%

mentioning

confidence: 98%

Lathyrism and Aging

Yeager¹

1968

Experimental Biology and Medicine

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“…5 With aging, lysyl oxidase activity decreases. 6 Therefore, BAPN should be treated in the young, rapidly growing animals, but not in the adults.…”

Section: Discussionmentioning

confidence: 98%

Comparison of β-aminopropionitrile-induced aortic dissection model in rats by different administration and dosage

Li¹,

Wang

et al. 2013

Vascular

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This study compared three β-aminopropionitrile (BAPN) treatment rats to find the optimal BAPN model for thoracic aortic dissection and aneurysm in one study. Sixty rats were divided into five groups: control, injected control, 0.25% and 0.4% BAPN treatment (orally), and 667 mg/kg/day BAPN injection subcutaneously. Incidence of aortic dissection and aneurysm, aortic weight and diameter were measured directly. Thickness of media and area of aorta were measured by hematoxylin and eosin and Victoria blue staining. The mortality, incidence of aortic dissection and the rupture rate of dissected aneurysm in 0.25% group was much higher than in the other two BAPN treatment groups. The diameter of thoracic aorta in 0.25% and the whole aorta in 0.4% group significantly increased. Media thickness and area of thoracic aorta were increased by 91% and 54% in 0.25% group, and by 17% and 12% in the BAPN injection group. Thickness and area were increased by 49% and 35% on thoracic aorta, and 29% and 46% on abdominal aorta in 0.4% group. In conclusion, 0.25%, 0.4% and BAPN injection groups might be appropriate for aortic dissection and pharmaceutical study, thoracic-abdominal aortic aneurysm or dilation and biomechanical research, respectively.

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“…As shown by Partridge, Elsden, and Thomas (41) for the desmosines and by Franzblau, Faris, and Papaioannou (42) for lysinonorleucine, these cross-linking amino acids are composed of lysine molecules. The severe fragmentation of arterial elastic membranes seen in lathyrism (43)(44)(45)(46) and copper deficiency (47,48) are believed to be due to the inhibition in the formation of cross-linking amino acids of newly formed elastin (49). It is possible that the splitting and fragmentation of arterial elastica in atherosclerosis also is related, at least in part, to such a metabolic defect.…”

Section: Intimal Elastin (A) Contents Of Elastin In Aortic Intimaementioning

confidence: 99%

The Protein and Lipid Composition of Arterial Elastin and Its Relationship to Lipid Accumulation in the Atherosclerotic Plaque

Kramsch¹,

Franzblau²,

Hollander³

1971

J. Clin. Invest.

181

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A B S T R A C T Elastin preparations from intimal layers and the media of normal and atherosclerotic human aortae were analyzed for protein and lipid content. In atherosclerotic aortae, elastin from plaques was compared with elastin from adjacent normal appearing areas of the same aorta.Arterial elastin purified by alkaline extraction appeared to be a protein-lipid complex containing free and ester cholesterol, phospholipids, and triglycerides. The lipid component of normal arterial elastin was small (1-2%). With increasing severity of atherosclerosis, there was a progressive accumulation of lipid in intimal elastin from plaques, reaching a mean lipid content of 37% in severe plaques. The increase in the lipid content of plaque elastin preparations wvas mainly due to large increases in cholesterol, over 80% of which was cholesteryl ester. This deposition of cholesterol in plaque elastin accounted for 20-34% of the total cholesterol content of the plaque. The increased lipid deposition in plaque elastin was associated with alterations in the amino acid composition of plaque elastin. In elastin from plaque intima, the following polar amino acids were increased significantly: aspartic acid, threonine, serine, glutamic acid, lysine, histidine, and arginine; whereas, cross-linking amino acids: desmosine, isodesmosine, and lysinonorleucine were decreased significantly. The amino acid and lipid composition of elastin from normal appearing aortic areas was comparable to that of normal arterial elastin except for intimal elastin directly adjacent to and medial elastin directly below the most severe plaques.

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Experimental lathyrism in mice

Cited by 19 publications

References 12 publications

Lathyrism and Aging

Lathyrism and Aging

Comparison of β-aminopropionitrile-induced aortic dissection model in rats by different administration and dosage

The Protein and Lipid Composition of Arterial Elastin and Its Relationship to Lipid Accumulation in the Atherosclerotic Plaque

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