Experimental lathyrism in tissue culture

A Combined Quantitative Chemical, Light, and Electron Microscope Study of Aortic Development in Normal and Nitrile‐treated Mice

“…Such a depression might, at critical stages of aortic growth and associated reniodeling, underlie aneurysms and ruptures. This opinion has since been supported by several sulisequent studies rn e~ivol-'Jti and in nitro 31 In the present paper, further evidence for or against this view has been sought by a combined histological, histocheinical, quantitative chemical, and EM study of the elastin and collagen contents. relative to age and body weight, in normal mice, in ztfcro and up to 30 da!…”

Azelnidipine suppresses the progression of aortic aneurysm in wild mice model through anti-inflammatory effects

“…13 Previous studies have demonstrated that the activity of lysyl oxidase decreases with aging 14,15 and that degeneration of elastic fibers is induced by b-aminopropionitrile (BAPN), an inhibitor of lysyl oxidase. [16][17][18] Recently, a mouse model of thoracic and abdominal AAs has been developed using the combination of angiotensin II-induced hypertension and BAPN-induced elastic lamina degeneration; however, the study was limited by a prohibitively high mortality rate. 16 Therefore, the first aim of this study is to establish a useful wild-type mouse model of AA with low mortality.…”