Experimental methods for measuring optical rotatory dispersion: Survey and outlook

Abstract

The measurement of optical rotation (OR) and optical rotatory dispersion has been finding renewed interest for some years, because of advancement in computational methods and in the performance of new experiments. Here, we shortly review the traditional and most-used experimental methods. We define and discuss the two main types of approaches in measuring OR: the intensity method and the optical null method. We report on some new results obtained by redesigning experiments based on the first approach, by adapting nonsophisticated hardware to current circular dichroism instrumentation.

Molecular Structure Determination Using Chiroptical Spectroscopy: Where We May Go Wrong?

“…Although not much talked about in recent literature, OR measurements suffer from artifacts as well, and one should not make routine measurements for turbid or colloidal solutions . A recent review on OR measurements is useful for recognizing the modern methods.…”

Use of a modified Drude's equation to investigate the optical rotation property of sugars

“…Such work was also conducted based on a glucose sensor by Ansari et al [6]. The ORD set up was also introduced to measure sucrose by positioning the sample between the horizontally and vertically oriented polarizers and comparing the results to commercial ORD apparatus using the intensity and optical null measurement methods [7]. Such work indicated that the use of polarizers with a fixed polarization state in the ORD set-up is appropriate for liquid measurements.…”

Experimental quantum polarimetry using heralded single photons

“…A variety of detection schemes have been developed for measuring the optical activity, i.e., analyzing the rotation of the linear polarization of light upon propagation through a chiral medium [9][10][11]. This rotation of the polarization has its origin in the different propagation constants for the two counter-rotating circularly polarized plane waves, which are eigenmodes of the chiral medium and into which the linear polarization can be decomposed.…”