2011
DOI: 10.1166/jnn.2011.3567
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Experimental Methods of Actuation, Characterization and Prototyping of Hydrogels for BioMEMS/NEMS Applications

Abstract: As a member of the smart polymer material group, stimuli responsive hydrogels have achieved a wide range of applications in microfluidic devices, micro/nano bio and environmental sensors, biomechanics and drug delivery systems. To optimize the utilization of a hydrogel in various micro and nano applications it is essential to have a better understanding of its mechanical and electrical properties. This paper presents a review of the different techniques used to determine a hydrogel's mechanical properties, inc… Show more

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Cited by 14 publications
(6 citation statements)
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“…Microfluidic devices with these properties have been built for lab-on-a-chip applications where the functions such as separation, mixing, reaction, synthesis and analysis are performed. 2 This micro device concept and technology, which has developed rapidly, is being applied increasingly in biological and chemical applications: [3][4][5] the * Author to whom correspondence should be addressed. fabrication of hydrogel for drug delivery systems, chemical and enzyme reactions, synthesis of nucleic acids and analysis of DNA (deoxyribonucleic acid) and protein.…”
Section: Introductionmentioning
confidence: 99%
“…Microfluidic devices with these properties have been built for lab-on-a-chip applications where the functions such as separation, mixing, reaction, synthesis and analysis are performed. 2 This micro device concept and technology, which has developed rapidly, is being applied increasingly in biological and chemical applications: [3][4][5] the * Author to whom correspondence should be addressed. fabrication of hydrogel for drug delivery systems, chemical and enzyme reactions, synthesis of nucleic acids and analysis of DNA (deoxyribonucleic acid) and protein.…”
Section: Introductionmentioning
confidence: 99%
“…Hydrogels are cross-linked polymer structures, which can absorb a large volume of water. Depending on external stimuli, they can change their volume (swelling or shrinking) more than 100-fold [49,50]. For developing a hydrogel-based actuator, we used the temperature-responsive hydrogel poly(N-isopropylacrylamide) (PNIPAAm), which is often used for fluidic applications [51,52].…”
Section: Hydrogel Shrinking Sensormentioning
confidence: 99%
“…15 Various experimental methods for determining the mechanical properties of hydrogels have been reviewed. 30 Various microfluidic schemes have been developed to apply mechanical forces on cultured cells or hydrogel scaffolds and examine its effect. Optical laser tweezers have been integrated with a microfluidic device to apply tensile and compressive forces on a single cell.…”
Section: -D Architecturementioning
confidence: 99%