Experimental modeling of head injury

Tsymbalyuk, V. І.; Kochin, O. V.

doi:10.25305/unj.108521

Cited by 8 publications

(1 citation statement)

References 17 publications

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“…TBI was modeled by a free-falling weight drop of 100g from a height of 80 cm on the parietal-occipital area of the head. (13) Blood samples were taken from the sublingual vein in an amount of 2.0 ml on Days 1, 3, 7, and 12 after the alteration. Such blood sampling technology simulates the fractional blood loss, which, during the 10 days of the posttraumatic period, was 32%-36% of the volume of circulating blood in the rats.…”

Section: Experimental Model Of Tbimentioning

confidence: 99%

Endogenous Intoxication and the Role of Antioxidants in Motion Activity Correction with Traumatic Brain Injury in Rat Model

Polozova¹,

Bojarinov²,

Ivashchenko³

et al. 2019

IJBM

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The aim of this study was to assess the effectiveness of cytoflavin and mexicor in the posttraumatic period of traumatic brain injury (TBI). Materials and Methods:The experiments were carried out on 60 white non pedigree female rats weighing 180-200 g, with 15 rats in each series. TBI was modeled by a free-falling weight drop of 100 g from a height of 80 cm on the parietal-occipital area of the head. Blood samples were taken from the sublingual vein in an amount of 2.0 ml on Days 1, 3, 7, and 12 after the alteration. After TBI, in Group 1, 15 rats received an intraperitoneal injection of 2-ethyl-6-methyl-3-hydroxypyridine succinate (mexicor) for 10 days in a daily dose of 8.0 mg/kg. In Group 2, 15 rats received an intraperitoneal injection of cytoflavin for 10 days in a daily dose of 0.2 ml/kg. The activity of lipid peroxidation and antioxidant protection system in the blood plasma was determined by a biochemicoluminescence method. Analysis of animal motion activity included the determination of the ability to balance and to stay at the wooden bar, time spent for moving on the bar from the bright light source to the darkroom, and paw slip frequency.Results: Mexicor and cytoflavin decreased the level of oxidative processes in rat model with TBI and the development of secondary brain injury. The positive dynamics in restoring pro-and antioxidant system balance was combined with positive changes in motor function.

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Section: Experimental Model Of Tbimentioning

confidence: 99%

Endogenous Intoxication and the Role of Antioxidants in Motion Activity Correction with Traumatic Brain Injury in Rat Model

Polozova¹,

Bojarinov²,

Ivashchenko³

et al. 2019

IJBM

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Relationship between Morphofunctional Changes in Open Traumatic Brain Injury and the Severity of Brain Damage in Rats

et al. 2016

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Functional and Biochemical Parameters of Erythrocytes during Mexicor Treatment in Posttraumatic Period after Experimental Blood Loss and Combined Traumatic Brain Injury

et al. 2017

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Mexicor treatment (8 mg/kg body weight per day) during the posttraumatic period after concomitant traumatic brain injury and acute blood loss in rats increased electrophoretic mobility and concentration of 2,3-diphosphoglycerate, and reduced malondialdehyde content in erythrocytes. These changes improved hemodynamics and oxygen-transporting function of the blood. The most pronounced effects of Mexicor were observed at the early stages of posttraumatic period.

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Experimental modeling of head injury

Cited by 8 publications

References 17 publications

Endogenous Intoxication and the Role of Antioxidants in Motion Activity Correction with Traumatic Brain Injury in Rat Model

Endogenous Intoxication and the Role of Antioxidants in Motion Activity Correction with Traumatic Brain Injury in Rat Model

Relationship between Morphofunctional Changes in Open Traumatic Brain Injury and the Severity of Brain Damage in Rats

Functional and Biochemical Parameters of Erythrocytes during Mexicor Treatment in Posttraumatic Period after Experimental Blood Loss and Combined Traumatic Brain Injury

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