Experimental models in orthopedic infection research

Odekerken, Jim C. E.; Welting, Tim J. M.; Walenkamp, G. H. I. M.; Arts, Jacobus J.

doi:10.1016/b978-0-08-100205-6.00005-7

Cited by 1 publication

(1 citation statement)

References 156 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Once an implant is inserted in the human body, two processes start to occur: bacteria attempt to colonize it, while tissue integration from the surroundings occurs; this phenomenon is known as “the race for the surface” [ 59 , 60 ]. The desirable outcome is that bacterial infection is inhibited, while tissue integration is promoted; the antibacterial results herein presented present BRT0 and BRT3 as potential candidates to eliminate bacteria at the implantation site, with their superior antibacterial conditions potentially allowing for bone cells to attach and proliferate around the implant in vivo .…”

Section: Discussionmentioning

confidence: 99%

Titanium addition influences antibacterial activity of bioactive glass coatings on metallic implants

Rodriguez

Stone

Schemitsch

et al. 2017

Heliyon

View full text Add to dashboard Cite

In an attempt to combat the possibility of bacterial infection and insufficient bone growth around metallic, surgical implants, bioactive glasses may be employed as coatings. In this work, silica-based and borate-based glass series were synthesized for this purpose and subsequently characterized in terms of antibacterial behavior, solubility and cytotoxicity. Borate-based glasses were found to exhibit significantly superior antibacterial properties and increased solubility compared to their silica-based counterparts, with BRT0 and BRT3 (borate-based glasses with 0 and 15 mol% of titanium dioxide incorporated, respectively) outperforming the remainder of the glasses, both borate and silicate based, in these respects. Atomic Absorption Spectroscopy confirmed the release of zinc ions (Zn2+), which has been linked to the antibacterial abilities of glasses SRT0, BRT0 and BRT3, with inhibition effectively achieved at concentrations lower than 0.7 ppm. In vitro cytotoxicity studies using MC3T3-E1 osteoblasts confirmed that cell proliferation was affected by all glasses in this study, with decreased proliferation attributed to a faster release of sodium ions over calcium ions in both glass series, factor known to slow cell proliferation in vitro.

show abstract

Section: Discussionmentioning

confidence: 99%