Abstract:Restrictive cardiomyopathy (RCMP) is characterized by the isolated diastolic ventricular dysfunction due to increased myocardial stiffness. Animal models of RCMP include the models of acquired and hereditary RCMP as well as the models in large animals. Acquired RCMP is observed in exogenous iron overload, radiation-induced myocardial fibrosis, eosinophilic myocarditis, systemic sclerosis, and amyloidosis. Genetic models of RCMP mimic clinical scenarios of hereditary hemochromatosis and sarcomeric protein mutat… Show more
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