Experimental oral infection of calves with Mycobacterium johnei

Gilmour, N.J.L.; Nisbet, D.I.; Brotherston, J G.

doi:10.1016/0021-9975(65)90033-2

Cited by 45 publications

(26 citation statements)

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“…Pathologic manifestations include chronic granulomatous enterocolitis and regional lymphangitis and lymphadenitis. 9 The pathology of natural 4 and experimental 13,24,31 paratuberculosis with varying degrees of gross and histologic lesions has been described in bovines. Buergelt et al 4 described mild, moderate, and advanced lesions in cattle based on the severity of lesions and pattern of cellular infiltration.…”

mentioning

confidence: 99%

“…12 Being a major domesticated ruminant in Asia, its importance with regard to control and eradication of paratuberculosis cannot be underestimated. Because buffaloes belong to a separate genus, Bubalus, the pathology of paratuberculosis infection in cattle 4,13,24,31 and other ruminants 5,10,16,25,26,28,34,37 is not likely to be similar. The objective of the present study was to describe the gross and histologic lesions of naturally occurring paratuberculosis in water buffaloes.…”

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confidence: 99%

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Pathology of Naturally Occurring Paratuberculosis in Water Buffaloes (Bubalus bubalis)

et al. 2006

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Abstract. Gross and histologic lesions of paratuberculosis were studied in water buffaloes. Small intestines and associated mesenteric lymph nodes of 405 water buffaloes were examined. Of these, 20 animals having visible changes of intestinal thickening, mucosal corrugations, and enlargement of mesenteric lymph nodes exhibited histologic alteration characteristics of mild to moderate granulomatous inflammation. The histologic lesions observed in these animals were classified into 3 grades on the basis of type of cellular infiltration, granuloma formation, and presence of acid-fast bacilli. Grade-1 lesions observed in 8 animals were marked by the presence of scattered epithelioid macrophages amid large number of lymphocytes in the intestinal villi and in the paracortical regions of the associated mesenteric lymph nodes. Another 8 animals classified under grade-2 revealed microgranulomas, infiltration with a larger number of epithelioid macrophages besides lymphocytes in the intestinal villi, and granulomas in the mesenteric lymph nodes. Grade-3 lesions observed in 4 animals were characterized by the presence of epithelioid granulomas and giant cells in the intestines and the mesenteric lymph nodes. The Ziehl-Neelsen's stained tissue sections revealed acid-fast bacilli in grade-3 and -2 animals and acid-fast granular debris in grade-1 animals. Among these 20 buffaloes, 14 (70%) were positive in the IS900 specific polymerase chain reaction and 6 (30%) were positive in the bacterial culture.

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Pathology of Naturally Occurring Paratuberculosis in Water Buffaloes (Bubalus bubalis)

et al. 2006

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“…Routes of infection have included oral challenge directly or via a stomach tube, inoculation into the crypt of the tonsil, and intravenous injection (15,24,27,34,39). These approaches have shown various results, with dissemination of M. avium subsp.…”

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confidence: 99%

Experimental Infection Model for Johne's Disease in Sheep

et al. 2005

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Johne's disease in ruminants results in chronic enteritis caused by the pathogenic bacterium Mycobacterium avium subsp. paratuberculosis. This study examined two M. avium subsp. paratuberculosis strains (JD3 and W), using different doses and routes of infection, to establish the optimal time postchallenge when predictable levels of infection, gut lesions, and clinical disease occur in a large proportion of sheep. While a small proportion (25%) of sheep challenged with a low-passage-number laboratory culture of M. avium subsp. paratuberculosis (strain W) became infected, no infection was found in animals exposed to a high-passagenumber culture isolate of strain W. In contrast, a primary tissue homogenate of M. avium subsp. paratuberculosis (JD3) resulted in high (90%) infection rates and gut histopathology following oral or intratonsillar challenge. The optimal conditions necessary to produce Johne's disease involve oral inoculation of 3-month-old lambs with four doses of 5 ؋ 10 8 CFU of M. avium subsp. paratuberculosis isolated directly from the gut lymphatic tissues of clinically affected sheep. This resulted in consistent gut histopathology at 9 months and the onset of clinical disease by 11 months postchallenge.

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“…Some of the earliest studies demonstrated cell-mediated immune (CMI) responses as an early host immune response in cattle (Taylor, 1953;Gilmour et al, 1965) that precedes the development of antibodies (Lepper et al, 1989;Stabel et al, 2003). This general pattern of immune responses is supported by recent detailed investigations of the role of specific immune and inflammatory cells and cytokines (reviewed by Coussens, 2004), although it also has been shown that antibodies to certain MAP antigens can appear during the early phase of infection (Koets et al, 2001;Waters et al, 2003).…”

Section: Sensitivity As a Function Of Agementioning

confidence: 82%

Opinion of the Scientific Panel on Animal Health and Welfare (AHAW) on a request from the Commission related to the risk of transmission of Mycobacterium avium subsp. paratuberculosis via bovine semen

2004

EFSA Journal

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Experimental oral infection of calves with Mycobacterium johnei

Cited by 45 publications

References 4 publications

Pathology of Naturally Occurring Paratuberculosis in Water Buffaloes (Bubalus bubalis)

Pathology of Naturally Occurring Paratuberculosis in Water Buffaloes (Bubalus bubalis)

Experimental Infection Model for Johne's Disease in Sheep

Opinion of the Scientific Panel on Animal Health and Welfare (AHAW) on a request from the Commission related to the risk of transmission of Mycobacterium avium subsp. paratuberculosis via bovine semen

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