Experimental pharmacological research regarding some newly synthesized benzamides on central nervous system functions

Abstract

Three newly synthesized benzamides by the Department of PharmaceuticalChemistry of the Faculty of pharmacy from the University of Medicine and Pharmacy "Carol Davila" Bucharest were tested in order to determine whether these new molecules have similar effects on the central nervous system as those already in therapeutic use belonging to the same chemical group, such as tiapride (neuroleptic) or lidocaine (local anaesthetic).Tests were carried out on NMRI mice which were given new compounds, conventionally named I5C, I14C, and II5C in a dose of 1/20 of the lethal dose 50% (LD50), as previously determined. They received this treatment daily for 21 days.The evasive-investigating capacity of mice was determined using the platform test, and the motor activity using an Activity cage device.The results have shown that compounds I5C and II5C decrease the investigation capacity of the mice; and compound I5C inhibits motor activity, while II5C stimulates it. Thus we concluded that only compounds I5C and II5C have a neuroleptic potential that might be investigated further.Acne conglobata is a rare, severe form of acne vulgaris characterized by the presence of comedones, papules, pustules, nodules and sometimes hematic or meliceric crusts, located on the face, trunk, neck, arms and buttocks.Cornel Chiriță et al.

2‐Aminothiazole‐Oxadiazole Bearing N‐Arylated Butanamides: Convergent Synthesis, Tyrosinase Inhibition, Kinetics, Structure‐Activity Relationship, and Binding Conformations

“…Normally, amides are classified into distinctive subclasses depending upon the number of nitrogen substituents. Primary amide produce by the replacement of the carboxylic hydroxy group by NH 2 while the secondary and tertiary amides are produced when one or both hydrogen in primary amides are substituted by other groups [14–15] . Recent researches indicated that butanamide derivatives are suitable lipoxygenase inhibitors, [16] histone deacetylase inhibitors, [17] and potent urease inhibitors [18] .…”

Experimental pharmacological research regarding some new quinazolin-4-ones derivatives

“…We followed all the existing protocols of the Laboratory of Pharmacology, the Faculty of Pharmacy, UMF "Carol Davila" Bucharest. We investigated the antidepressant effect using the forced swimming test, the anxiolytic/ anxiogenic effect using the suspended plus-shaped maze (Ugo Basile), the effect on the motor activity with the Ugo Basile activity cage, and the potential analgesic effect using the hot plate test, Ugo Basile (14).…”

Experimental pharmacological research regarding the antidepressant effect of associating doxepin and selegiline in normal mice

“…Selegiline acts in 3 ways: it reduces dopamine biotransformation through the inhibition of type B monoamine oxidase; it inhibits the dopamine reuptake; and it stimulates dopamine synthesis by blocking the presynaptic dopamine receptors (7). Although many therapeutic options are currently available, there are still cases of antidepressant-resistant depressions that require either new molecules (8)(9)(10)(11) or new approaches in managing these disorders (12). Given that a new drug requires significant time and financial resources, combining existent therapies may prove to be a viable solution for treating complex atypical depressions.…”

“…Assessment of motor activity was conducted to assess the effect on the central nervous system by recording the horizontal and vertical movements of each mouse in the Ugo Basile -Activity Cage. The animals were placed individually in a corner of the cage and their movements were recorded for 5 minutes by IR photoelectric cell sensors (9,13).…”