Experimental Pre-Thrombotic State of an Organism resulting from the Dysfunction of the Physiological Anticoagulating System induced by an Atherogenic Diet

Kudrjashov, B. A.; Bazasian, G.G.; Sytina, N. P.; Andreenko, G. V.

doi:10.1038/189067a0

Nature

1961

DOI: 10.1038/189067a0

|View full text |Cite

Experimental Pre-Thrombotic State of an Organism resulting from the Dysfunction of the Physiological Anticoagulating System induced by an Atherogenic Diet

B. A. Kudrjashov

G.G. Bazasian

N. P. Sytina

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1963

1984

Publication Types

Select...

Article6

Relationship

Self Cite0

Independent6

Authors

Journals

Cited by 14 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By the addition of saturated fat to this type of diet, Thomas and Hartroft (4) were able to show that myocardial infarction could be produced even if the vitamin D was omitted. A number of other authors have published data on blood coagulation in similar animals (5,6,7,8); from these studies it is fairly certain that a marked elevation of many coagulation factors was present in these rats. It has been postulated that a "hypercoagulable" state is an important factor in the genesis of the infarcts (9) .…”

mentioning

confidence: 91%

Changes in Blood Coagulation and Fibrinolysis in Rats Fed Atherogenic Diets

Merskey¹,

Wohl²

1963

Thromb Haemost

View full text Add to dashboard Cite

Summary1. Groups of rats were fed thrombogenic diets and the effects on blood coagulation and fibrinolysis assessed.2. Animals fed a diet containing cholesterol, thiouracil and cholic acid developed high levels of coagulation factors I, II, V, VII—X, VIII, IX and X.3. Animals fed a similar diet with additional 40% beef fat developed even greater elevation of V, VII—X, VIII and X, similar elevation of factor II, and lesser (but still significant) elevation of factors I and IX. In addition marked elevation of blood platelets occurred.4. Euglobulin lysis time of the group not fed the additional fat was longer than in controls. Significant prolongation of euglobulin lysis time was not found in the group fed additional fat.5. If the increased levels of plasma fibrinogen were taken into account, it was found that a larger amount of fibrin was lysed per unit time in the euglobulin lysis test with plasma from rats fed either atherogenic diet compared with controls.6. Defective thromboplastin generation was present in both groups of rats fed an atherogenic diet. The defect was present in the serum and was not due to lack of a factor required for thromboplastin generation. An inhibitor was present in the serum which was capable of preventing the action of normal serum.7. No good correlation was found between the occurrence of changes in blood coagulation or fibrinolysis and the presence or absence of thrombosis and infarction.8. The exact cause of these anomalies remains unexplained, as does the cause of the thrombosis in these animals. Starvation per se does not account for these abnormal findings. They could not adequately be explained on the basis of “hypercoagulability” of the blood.

show abstract

mentioning

confidence: 91%

Changes in Blood Coagulation and Fibrinolysis in Rats Fed Atherogenic Diets

Merskey¹,

Wohl²

1963

Thromb Haemost

View full text Add to dashboard Cite

show abstract

Lipoprotein lipase as humoral agent of the physiological anticlotting system

et al. 1964

View full text Add to dashboard Cite

Depression of the functioning of the physiological anticoagulatory system in experimental radiation sickness of animals

Pastorova

Kudryashov

1963

Bull Exp Biol Med

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Experimental Pre-Thrombotic State of an Organism resulting from the Dysfunction of the Physiological Anticoagulating System induced by an Atherogenic Diet

Cited by 14 publications

References 7 publications

Changes in Blood Coagulation and Fibrinolysis in Rats Fed Atherogenic Diets

Changes in Blood Coagulation and Fibrinolysis in Rats Fed Atherogenic Diets

Lipoprotein lipase as humoral agent of the physiological anticlotting system

Depression of the functioning of the physiological anticoagulatory system in experimental radiation sickness of animals

Contact Info

Product

Resources

About