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The fluidity of blood in a healthy organism is kept by means of reflex reaction initiated by thrombin appearing in blood stream in a threshold concentration. Heparin and activator of plasminogen are excreting in blood as a result of the reflex act. Heparin forms the complexes with fibrinogen, factors XIII, plasminogen, adrenalin and other factors. These compounds act as antiaggregating and antistabilizing agents on the fibrin monomer. They dissolve non-stabilized fibrin, even in the presence of EACA or antiplasmin. Complex plasmin-heparin carries out the enzymatic lysis of stabilized fibrin in the presence of the same inhibitors of fibrinolysis. The clearance of I131-thiombin in blood stream depends from the eomplexing of enzyme with heparin. Complex Thrombin-heparin is absorbed in liver. The accumulation of other heparin complexes take place in the lungs, what is important for quick lysis of fibrin monomer aggregates in the vessels of this organ.

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