Nonenzymatic Fibrinolysis and Its Role in the Organism

Kudrjashov, B. A.; Lyapina, L. A.

doi:10.1007/978-1-4684-1659-6_2

Cited by 22 publications

(2 citation statements)

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“…The solution of sodium citrate (3.8%) served as an anticoagulant. The following parameters of coagulant and anticoagulant plasma systems were evaluated: TFA, NEFA [9], tissue plasminogen activator activity [8], and anticoagulant activity (test for activated partial thromboplastin time, APTT) [4]. Platelet aggregation in the plasma was studied on an aggregometer.…”

Section: Methodsmentioning

confidence: 99%

Changes in hemostatic parameters after intranasal administration of peptide Pro-Gly-Pro

2007

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Anticoagulant activity, total and nonenzymatic fibrinolytic activity, and tissue plasminogen activator activity increased, while platelet aggregation and activity of factor XIIIa in rat blood plasma decreased over 3 h after single intranasal administration of proline-containing peptide Pro-Gly-Pro. Hemostatic parameters in rats 24 h after single administration of this peptide did not differ from the control level observed in animals receiving 0.85% NaCl.

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Section: Methodsmentioning

confidence: 99%

Changes in hemostatic parameters after intranasal administration of peptide Pro-Gly-Pro

2007

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“…The following biochemical parameters of blood plasma were assessed: total (TFA) and nonenzymatic fibrinolytic activity (NFA) (Kudrjashov and Lyapina, 1986), the activity of plasminogen tissue activator (TPA activity) (Astrup and Müllertz, 1952), the acti vated partial thromboplastin time (APTT) (Dolgov et al, 2005), Hageman dependent (XIIa) fibrinolysis (HDF) using the test setup (Scientific Production Firm Renam, Russia), and the general fibrinolytic activity (GFA) using the lysis time of euglobulin frac tion (EF) of blood plasma. In blood plasma enriched with platelets, aggregation of the former was detected by the method of Berkovskii et al (2003) with 2-5 μM of adenosine 5 diphosphate (ADP) solution as an aggregant; the detection was done using an aggregom eter (Moscow State University, Russia).…”

Section: Correction Of Impairments In Functions Of Anticoagulation Anmentioning

confidence: 99%

Correction of impairments in functions of anticoagulation and insular systems of an organism by the regulatory peptide Leu-Pro-Gly-Pro

Myasoedov

Andreeva

Lyapina

et al. 2013

Biol Bull Russ Acad Sci

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It has been established that fivefold intranasal administration of the peptide Leu⎯Pro⎯Gly⎯Pro (1 mg/kg) to rats with developing refractory hyperglycemia leads to restoration and normalization of the functions of anticoagulation and insular systems. In the blood of experimental animals, there was a decrease in the sugar level and platelet aggregation and an increase in anticoagulant and all kinds of fibrinolytic (total, enzymatic, non enzymatic, Hageman dependent) activity.

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