Experimental Production by Œstrin of Pituitary Tumours With Hypopituitarism and of Mammary Cancer

Horning, E. S.

doi:10.1016/s0140-6736(01)18015-3

Cited by 103 publications

(9 citation statements)

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“…Wolfe (1936) studied the action of this dibenzanthracene diol on the pituitary and found that it prevented the changes which occur after castration and also induced extreme degranulation of the basophiles and moderate degranulation of the eosinophiles. In this comparison between the effects of carcinogenic and oestrogenic substances it may be noted that Cramer and Horning (1936) described arrest of cell division in the mouse testis after prolonged treatment with oestrin, while Tuchmann (1936;also Tuchmann and Demay 1936) obtained similar regressive changes following the administration of either folliculin or 3:4-benzpyrene in guinea-pigs.…”

Section: Growth Rate Of Transplantable Tum Oursmentioning

confidence: 84%

The influence of various polycyclic hydrocarbons on the growth rate of transplantable tumours

1937

Proc. R. Soc. Lond. B

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[Plates 23, 24] I -I n t r o d u c t o r yAs a result of considerations which will be discussed to some extent in the present paper, experiments were carried out to test the effect of certain of the carcinogenic hydrocarbons, studied at the Research Institute of the Royal Cancer Hospital (Cook and others 1932;Cook 1932; Barry and others 1935) on the growth rate of transplantable animal tumours. The work was also extended to include related non-carcinogenic hydrocarbons and other substances. A short preliminary account has already been published (Haddow 1935).II-E x p e r im e n t a l 1-Animals-The majority of the animals used were hooded rats of the Lister Institute strain, since previous experience had shown these to be particularly suitable for use with the Jensen and Walker tumours. Wistar rats from the Glaxo laboratories proved susceptible to the Walker tumour and were also used on a few occasions. Batches were selected in which the animals were in perfect condition and of reasonable uniformity of weight (usually 100-150 g.). 2-Tumour strains and Technique of I inplantation-The rat tumours studied were the Jensen sarcoma and Walker carcinoma (strains supplied by the Imperial Cancer Research Fund); a sarcoma (LR-10) induced in the

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Section: Growth Rate Of Transplantable Tum Oursmentioning

confidence: 84%

The influence of various polycyclic hydrocarbons on the growth rate of transplantable tumours

1937

Proc. R. Soc. Lond. B

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“…Its action was in the case of line R3 to hasten the appearance of the tumours, which were found at six months instead of twelve, and in the other lines to make cancer appear at the twelfth month in animals which normally were able to live to the age of two years without showing any cancer. (41,42) and by McEuen, Selye and Collip (90) in animals receiving oestrin, amounting in some cases to adenoma. Cramer and Horning found diminution or almost complete disappearance of chromophil (acidophil and basophil) cells, with congestion and haemorrhage in mice (male and female, castrated and uncastrated) ; the predominant cell in the adenomas is therefore chromophobe.…”

Section: Vz Comparison Of Various Carcinogenic Compounds In Differenmentioning

confidence: 94%

Chemical Compounds as Carcinogenic Agents

Cook¹,

Haslewood²,

Hewett³

et al. 1937

The American Journal of Cancer

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CHEMICAL RELATIONSHIPS Group I : Cholanthrene DerivativesThe carcinogenic compounds of the cholanthrene group merit separate consideration on account of their chemical relationship to the cholane (bile acid) class of naturally occurring substances. They are, however, of essentially the same type as the benzanthracene derivatives (see p. 222).Methylcholanthrene was prepared independently by Wieland and Dane (125) and by Cook and Haslewood (35) by dehydrogenation of dehydronorcholene, a pentacyclic hydrocarbon obtained in 1925 by Wieland and Schlichting (126) from the bile acid, deoxycholic acid, by simple chemical transformations. The molecular structure of methylcholanthrene was proved by its degradation by Cook and Haslewood (36) to 5 : 6-dimethyl-1 : 2-benzanthraquinone, identical with a specimen prepared synthetically by a method which established its constitution. The synthesis of methylcholanthrene by Fieser and Seligman ( 5 1 ) is in complete harmony with this structure, and the conversion of cholic acid into methylcholanthrene has been reported by Fieser and Newman (48). Cholic acid and deoxycholic acid are the two principal acids of human bile, so that in these reactions we have a comparatively simple chemical transformation of important constituents of the human body into a cancer-producing hydrocarbon related in structure to those already known. The interest of these relationships needs no further emphasis. So far it has not been possible to secure evidence that the production in the body of methylcholanthrene or a related compound is an aetiological factor in human cancer.The parent pentacyclic aromatic hydrocarbon, cholanthrene, has also been synthesised, both in London and at Harvard (38,53). The biological testing of cholanthrene and methylcholanthrene has shown that these two hydrocar-

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“…McEuen [1936] obtained similar results. These writers described the enlargement of the rat hypophysis which occurs after oestrin injections ; this has been found in mice and rats of both sexes, by numerous other workers including Hohlweg [1934], Korenchevsky and Dennison [1934], Nelson [1934], Wolfe and Phelps [1935], Cramer and Horning [1936a], and McEuen, Selye, and Collip [1936] after administration of oestrogenic substances. In rats so treated for 7-11 months tumours of the anterior pituitary gland weighing up to 250 mg. may be formed [Zondek, 19366, 1937;McEuen et al, 1936;Wolfe and Wright, 1938].…”

Section: Introductionmentioning

confidence: 99%

Depression of Hypophyseal Activity by the Implantation of Tablets of Oestrone and Oestradiol

Deanesly¹

1939

Journal of Endocrinology

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Experimental Production by Œstrin of Pituitary Tumours With Hypopituitarism and of Mammary Cancer

Cited by 103 publications

References 0 publications

The influence of various polycyclic hydrocarbons on the growth rate of transplantable tumours

The influence of various polycyclic hydrocarbons on the growth rate of transplantable tumours

Chemical Compounds as Carcinogenic Agents

Depression of Hypophyseal Activity by the Implantation of Tablets of Oestrone and Oestradiol

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