Experimental production of diffuse pulmonary fibrosis and alveolitis in cattle: the effects of repeated dosage with 3, methyl indole

Logan, A.T.; Selman, I.E.; Wiseman, A; Allan, E.M.; Pirie, H. M.

doi:10.1016/s0034-5288(18)32291-4

Cited by 9 publications

(1 citation statement)

References 12 publications

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“…This substance causes cellular damage on type 1 pneumocytes and on the non-ciliated bronchiolar epithelium (Club cells), resulting in severe pulmonary edema and emphysema, presence of hyaline membranes, and hyperplasia of the alveolar epithelium (Carlson et al 1972, Bray & Emmerson 1994, Woolums 2015, Constable et al 2017. This disease has already been reproduced in cattle experimentally by ingestion of L-tryptophan (Carlson et al 1972, Wicpolt et al 2014) and directly by 3MI (Bradley & Carlson 1980, Logan et al 1983.…”

Section: Introductionmentioning

confidence: 96%

Acute and chronic bovine pulmonary edema and emphysema in Uruguay

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An outbreak of pulmonary edema and emphysema with acute and chronic cases is reported in a farm in Uruguay. In a herd of 40 Hereford steers, 20 died. The deaths began four days after a change of paddock, from an old pasture of Avena sativa to a lush growing pasture of the same grass. Acutely affected animals showed severe dyspnea, sialorrhea, cough, and subcutaneous edema, and died within 72 hours. Chronically affected steers showed dyspnea, respiratory noises, weight loss, and intolerance to exercise. The deaths began four days after the change of paddock. Ten days after the first death, the steers were withdrawn from the pasture, but continued dying throughout the following 40 days. Twenty animals died and six were necropsied. Grossly, the lungs were diffusely armed and glistening, with reddish and crepitant cut surface, and presented alveolar septae sharply distended by edema and emphysema. There was subpleural emphysema with air blebs distributed across the pleural surface. Presence of Dictyocaulus viviparus was observed in three steers. In some animals, the trachea was diffusely reddish with presence of pink foam; in some others, there was bloody liquid in the tracheal lumen. Histologic examination showed severe diffuse alveolar and interstitial emphysema, hyaline membranes adhered to the alveolar wall, thickening of the interlobular septae with proliferation of type II pneumocytes, and moderate-to-severe multifocal histiocytic, neutrophilic and eosinophilic infiltrate. In the trachea, there was submucosal hemorrhage and moderate multifocal eosinophilic and lymphocytic infiltrate. The steers with chronic signs presented similar lung lesions, but multifocal pulmonary fibrosis and cardiac dilatation were also observed. The diagnosis of acute bovine pulmonary emphysema and edema (ABPE) was based on the occurrence of the disease after introduction of the herd in a lush green pasture, on the characteristic gross and histologic lesions, and on the absence of other toxic or infectious agents causing similar lesions. Cattle raisers should be alert to the risks of occurrence of this disease after the introduction of the herds into paddocks with green and lush pastures.

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Section: Introductionmentioning

confidence: 96%

Acute and chronic bovine pulmonary edema and emphysema in Uruguay

et al. 2018

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Kwashiorkor

Reid¹

1984

Medical Hypotheses

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Kwashiorkor kills millions of young children in the tropical Third World. It was believed to be a disease of protein starvation. The medical team headed by Professor Ralph Henrickse of the Liverpool School of Tropical Medicine has discovered that aflatoxin, a fungus toxin, may be the triggering factor in this disease which also impairs liver function. In New Zealand, we have a pasture fungus, the spores of which produce a liver toxin that has killed millions of animals this century and impaired the performance of millions more. New Zealand is a pastoral farming country with 70 million sheep and several million cattle. We now protect the animal with zinc medication. This paper describes the similarities between Kwashiorkor and the mycotoxic liver disease in New Zealand livestock, known locally as Facial Eczema. It describes briefly my discovery that pharmacological doses of zinc protected farm animals from pasture contaminated with the spores of the fungus Pithomyces chartarum, which contains the toxin sporidesmin. This paper proposes that Kwashiorkor and Facial Eczema are diseases with similar beginnings and a common end.

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Sudden Infant Death Syndrome

Reid

1987

Medical Hypotheses

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Experimental production of diffuse pulmonary fibrosis and alveolitis in cattle: the effects of repeated dosage with 3, methyl indole

Cited by 9 publications

References 12 publications

Acute and chronic bovine pulmonary edema and emphysema in Uruguay

Acute and chronic bovine pulmonary edema and emphysema in Uruguay

Kwashiorkor

Sudden Infant Death Syndrome

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