Experimental Production of Syndrome of Obesity, Hyperinsulinemia and Hyperlipidemia in Monkeys

Longitudinal studies of the rhesus monkey reveal a syndrome of diabetes mellitus in those that become middle-aged and obese. The sequence of events in the development of the disease progresses from normoinsulinemia with normoglycemia through stages of hyperinsulinemia followed by below normal insulin levels with hyperglycemia and glycosuria. We believe the rhesus to be an excellent nonhuman primate model for maturity-onset diabetes in humans.

Section: Resultsmentioning

confidence: 93%

The Course of Development of Glucose Intolerance in the Monkey (Macaco mulatta)

Cl¹,

Ciaccia²

1978

“…The only comparable study of the growth rate of another group of mon keys through seven years of age was that conducted by Van No previous studies of the incidence of obesity are available for any species of monkey. However, Hamilton et al [9] described seven obese M. mulatta, most of which were older males caged for many years. Their group of long-term monkeys included both males and females, but only males be came obese.…”

Section: Discussionmentioning

confidence: 99%

“…In the only report of spontaneously occurring obesity in monkeys, Hamilton et al. [9] described the characteristics of seven nondiabetic rhesus monkeys (Macaca mulatta) over 12 years old. Further longitudinal studies of the in cidence and characteristics of spontaneous obesity in monkeys are likely to provide valuable knowledge about the development and management of hu man obesity.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Obesity in Pigtailed Monkeys (Macaca minestrina)

Walike¹,

Goodner²,

Koerker³

et al. 1977

Obesity was studied in a colony of 873 Macaca nemestrina to establish tools for epidemiologic studies, to examine a genetic form of obesity, to document age/sex relationships to obesity, and to compare metabolic profiles of obese and normal monkeys. Age/weight growth curves were analyzed to select the most obese monkeys and age- and sex-matched normal controls. Degree of adiposity was determined using tritiated water for estimation of lean body mass. Body weight, anterior trunk height, and abdominal and triceps skinfolds were measured. Fasting insulin, fasting free fatty acids, and glucose disappearance rate were determined. The results give evidence of similarities between macaque and human obesity.

“…Several reports in the recent literature have described the development of spontaneous diabetes mellitus in laboratory primates [2,[5][6][7]. Such dis coveries offer an opportunity for the close study of the developmental phase of the disease state.…”

Section: Introductionmentioning

confidence: 99%

Feeding Behavior in Monkeys with Spontaneous Diabetes mellitus

Cl¹

1975

In our laboratory, monkeys (Macaco mulatta) that attain middle age (10-14 years) and a body weight of over 15 kg often develop spontaneous diabetes mellitus. In some animals the development of the disease is accompanied by polyphagia and polydipsia. The polyphagia appears to be in response to loss of body weight. Gross estimates of energy balance in diabetic monkeys indicate that the daily maintenance cost (kcal) of diabetes is greater during the untreated phase of the disease than in the pre-diabetic state.