Feeding Behavior in Monkeys with Spontaneous
Diabetes mellitus

Cl, Hamilton

doi:10.1159/000459848

Cited by 7 publications

(3 citation statements)

References 8 publications

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“…Subjects with glucosuria, who lose large amounts of glucose and related energy by urine excretion, increase food intake for compensation. 27 The origin of circulating VEGF in our study is uncertain. Previous findings indicate that the hypothalamus, pituitary and adrenal gland participate in VEGF production and secretion.…”

Section: Discussionmentioning

confidence: 75%

High plasma VEGF relates to low carbohydrate intake in patients with type 2 diabetes

et al. 2006

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Objective: Vascular endothelial growth factor (VEGF) has been suggested to enhance glucose transport across the blood-brain barrier, thereby increasing brain glucose supply. Increased brain glucose concentration is known to suppress food intake and to decrease body mass via action on hypothalamic regulation centers. Based on the crucial role of VEGF on brain glucose supply, we hypothesized that higher VEGF concentrations are associated with lower food intake and body mass in humans. Methods: Intending to investigate subjects with high variance of blood glucose, we examined patients with type 2 diabetes mellitus. Our hypothesis was tested in a population-based cohort of 190 subjects with type 2 diabetes. Plasma VEGF levels in conjunction with other parameters known to modulate food intake were measured and subsequently correlated with food intake patterns at a breakfast buffet as well as with body mass. Results: We found that subjects with higher concentrations of plasma VEGF had 17% less carbohydrate intake (P ¼ 0.003) and 4.8% lower body mass (P ¼ 0.017) than those with lower VEGF concentrations. Intake of protein and fat did not correlate with VEGF concentrations. These associations of plasma VEGF were confirmed in multiple linear regression analyses controlling for several parameters interacting with food intake. Conclusion: We conclude that high plasma VEGF concentrations are associated with less carbohydrate intake and lower body mass in type 2 diabetes. The role VEGF plays in facilitating glucose access to the brain represents a new aspect of food intake regulation and energy homeostasis, with relevance for diseases with body mass disturbances.

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Section: Discussionmentioning

confidence: 75%

High plasma VEGF relates to low carbohydrate intake in patients with type 2 diabetes

et al. 2006

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“…A number of multifactorial diseases have been reported in captive rhesus macaque colonies, e.g., endometriosis [Hadfield et al, 1997;Coe et al, 1998], colon cancer ], late-onset diabetes mellitus [Hamilton & Lewis, 1975], and asthma [Patterson & Harris, 1992]. However, a prerequisite for mapping genes in the rhesus macaque is the development of a genome-wide set of microsatellite markers.…”

Section: Introductionmentioning

confidence: 99%

Toward developing a genome‐wide microsatellite marker set for linkage analysis in the rhesus macaque (Macaca mulatta): Identification of 76 polymorphic markers

Hadfield

Pullen

Davies

et al. 2001

American J Primatol

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Linkage analysis can be problematic in humans because of the lack of large, multigenerational pedigrees and the difficulties in obtaining phenotypic data on all family members. In contrast, large, captive colonies of rhesus macaque are a potentially valuable resource for linkage studies because detailed phenotypic and genealogical data are kept, inbreeding is avoided, and DNA samples can usually be obtained. Microsatellite marker sets for genome-wide screening are available in a number of species, but not for the rhesus macaque. We tested primers to 400 human microsatellite markers from a genome-wide mapping set using DNA from nine unrelated female rhesus macaques. We found that 76 (19%) of the primers amplified a polymorphic product using the standard protocols for human DNA. The average heterozygosity of the markers in humans was 0.80, compared to 0.65 in the rhesus macaques. This study provides preliminary data, which could be used toward the development of a linkage mapping set in this species. There would be a need, however, to confirm the Mendelian inheritance of the markers.

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“…This is consistent with the finding of Howard et a1 [1986] that age was not a significant determinant of glucose intolerance in the Cay0 Santiago rhesus macaques. None of our abnormal individuals was obese ( Table I), suggesting that this factor is not of the same importance in these free-ranging macaques as it is among captive monkeys [Hamilton & Lewis, 1975;Hamilton & Ciaccia, 19781 and humans [DeFronzo, 1979;Rowe et al, 19831. Further, as among the female rhesus studied by Howard et a1 [1986], gestational glucose intolerance was not observed among the females we examined none of the three females documented as pregnant by mCG levels showed any noticeable elevation of blood glucose.…”

Section: Discussionmentioning

confidence: 86%

Prevalence of glucose intolerance in free‐ranging Macaca fascicularis of Mauritius

Dunaif¹,

Tattersall

1987

American J Primatol

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Oral glucose tolerance tests (OGTTs) were carried out on 30 free-ranging long-tailed macaques (Macaca fascicularis) on the island of Mauritius, following the suggestion that severe glucose intolerance and diabetes mellitus might be prevalent in this macaque population. OGTTs revealed no evidence of frank diabetes mellitus in the sample. However, 13% of individuals showed impaired glucose tolerance, with preserved insulin secretion, suggesting the presence of the target tissue resistance to insulin characteristic of human noninsulin-dependent diabetes mellitus (NIDDM). The macaques with impaired glucose tolerance were neither obese nor aged. Glucose levels at all time points of the OGl" in normal macaques in our free-ranging sample were lower than reported in captive populations, perhaps due to greater physical activity. Our observations demonstrate that a genetic predisposition to glucose intolerance does exist in M. fascicularis, and that this condition, well documented in laboratory macaques, is not simply an artifact of captivity.

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Feeding Behavior in Monkeys with Spontaneous Diabetes mellitus

Cited by 7 publications

References 8 publications

High plasma VEGF relates to low carbohydrate intake in patients with type 2 diabetes

High plasma VEGF relates to low carbohydrate intake in patients with type 2 diabetes

Toward developing a genome‐wide microsatellite marker set for linkage analysis in the rhesus macaque (Macaca mulatta): Identification of 76 polymorphic markers

Prevalence of glucose intolerance in free‐ranging Macaca fascicularis of Mauritius

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