Experimental reconstruction of the tracheal carina

Trachealagenesie: Welche chirurgischen Maßnahmen sind sinnvoll?

“…Alle Versuche, einen Trachealersatz zu finden, der einen ernsthaften klinischen Einsatz rechtfertigen könnte, sind bis heute ohne brauchbares Ergebnis~das gilt sowohl für Kunststoffprothesen aller Art (3,5,6,9,23,27) als auch für Versuche mit autologem Material, z. B. Ösophagus (13) oder Blasenschleimhaut (20,25).…”

Tracheal replacement revisited: Use of a vascularized tracheal transplant in a porcine model

“…Over the years there have been various different approaches attempted in tracheal replacement. There have been a variety of different foreign materials used to replace the trachea such as stainless steel, 5,6 tight coils of steel wire, 7 vitallium, 5,8 glass, 5 polyethylene, 9 Lucite, 7,8 silicone, [10][11][12][13] Teflon, 6,14,15 Ivalon, 8,16 polyvinyl chloride, 17 polyethylene, polyurethane, Silastic, Teflon combinations, 18 rigid and flexible Silastic with Dacron cover, 19 and tubes of Teflon, Ivalon, and Silastic. 20 Because these materials do not become incorporated into the local tissues, problems with migration, dislodgement, erosion, infection, and obstruction were common because mucosalization of these foreign bodies did not occur.…”

“…Tissue engineering techniques have been described by a variety of different groups over the years utilizing fresh devascularized autografts, fresh devascularized allografts, and preserved devascularized allografts. 2,10,20 Results were often poor, mostly with ischemic necrosis of the mucosa, submucosa, and cartilage. More recently, inducing the formation of a neotrachea by introducing cultivated cells into a framework of biodegradable synthetic polymer or cadaveric lyophilized cartilage has been described experimentally and clinically.…”

“…Because cadaveric cartilage transplantation has not resulted in an effective solution of replacing a trachea, tissue engineering techniques (i.e., cultivating cells that are introduced into a framework) have evolved in an effort to reliably replace the trachea. Tissue engineering techniques have been described by a variety of different groups over the years utilizing fresh devascularized autografts, fresh devascularized allografts, and preserved devascularized allografts . Results were often poor, mostly with ischemic necrosis of the mucosa, submucosa, and cartilage.…”

Identification and Characterisation of tracheal cartilage derived stem cells for airway tissue engineering

“…Vast majority of synthetic materials have been used in pre-clinical testing in large animal such as glass [70], polyethylene [71], silicone [72], stainless steel [73] and Teflon™ [74]. Clinical trials have also been carried out with stainless steel [75], steel coil [76], silicone [77], polythene [78] and Teflon™ [79].…”