AISI-D6 steel is widely used in the creation of dies and molds. In the present paper, first the electrical discharge machining (EDM) of the aforementioned material is performed with a testing plan of 32 trials. Then, artificial neural networks (ANN) and adaptive neuro-fuzzy inference system (ANFIS) were applied to predict the outputs. The effects of some significant operational parameters—specifically pulse on-time (Ton), pulse current (I), and voltage (V)—on the performance measures of EDM processes such as the material removal rate (MRR), tool wear ratio (TWR), and average surface roughness (Ra) are extracted. To lead the process operators, process plans (i.e., parameter–effect correlations) are created. The outcomes exposed the upper values of pulse on-time caused by higher amounts of MRR and Ra, and likewise lower volumes of TWR. Furthermore, growing the pulse current resulted in upper volumes of the material removal rate, tool wear ratio, and surface roughness. Besides, the higher input voltage resulted in a lower amount of MRR, TWR, and Ra. The estimation models developed by using experimental data recounting MRR, TWR, and Ra. The root means the square error was used to determine the error of training models. Furthermore, the estimated outcomes based on the models have been proven with an unseen validation set of experiments. They are found to be in decent agreement with the experimental issues. The investigation shows the powerful learning capability of an ANFIS model and its advantage in terms of modeling complex linear machining processes.