Experimental Studies on Cx-Reactive Protein in Rabbit Aqueous

Studies of Synovial and Serum C-Reactive Protein in Experimental Arthritis in Rabbits

“…Such a mechanism has been proposed ( S ) , and could account for the immunohistologic localization of rabbit CRP in sites of inflammation but not in liver ( 6 ) . In addition, this mechanism would explain the finding of CRP in synovial fluid, but not in serum, of some patients with various arthritides (7), as well as the evidence suggesting local production of CRP in rabbit aqueous following induction of uveitis (8). However, the report that CRP appears in blood before appearing in blister fluid in human burns is inconsistent with this thesis (9), suggesting that CRP is not formed at the inflammatory site.…”

The Significance of C-Reactive Protein Determinations in Inflammatory Conditions of the Eye

“…W olkowicz et al (21) offered convincing proof as to the exis tence of intraocular CRP production in response to various bac teria injected into the vitreous body of rabbits. According to Wood (22), CRP would introduce antibody form ation, as a link in the chain of events.…”

Nonspecific Resistance to Intraocular Infection I. Elicitation of Resistance by Neisseria meningitidis

“…Although CxRP could also be induced in the left eyes by the pneumococci, it would not have done so before the organisms would have been present already when the pneumococci were injected. Wolkowicz et al (27) showed that CxRP was present in the aqueous humor of rabbits with uveitis induced by typhoid vaccine, streptococci, and staphylococci. CxRP appeared within 24 h, and titers were higher in the aqueous humor than in serum, suggesting that it was produced locally (within the eye).…”