Experimental studies on the regenerating lens and the eye in adult Triturus viridescens

Stone, L. S.; Chace, Robert R.

doi:10.1002/ar.1090790306

Cited by 23 publications

(4 citation statements)

References 14 publications

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“…This is consistent with earlier work by Stone and Chace [14] showing that in Notophthalmus viridescens, the regenerated lens takes a long time to approach its original size. The 9-week old lenses also have a significantly shorter focal length than the original lenses.…”

Section: Discussionsupporting

confidence: 93%

“…Even at this stage, however, we found that the diameter of the lens is still smaller than the original lens, in agreement with Stone and Chase [14]. All other results suggest that the regenerated crystalline lens is functionally equivalent to an original lens except for its lower light transmission.…”

Section: Discussionsupporting

confidence: 90%

“…Furthermore, the timing of complete regeneration, including growth to the original size, varies significantly depending on the study. Stone and Chace [14] suggested that the regenerated lens doesn't attain the size of the original lens, even after a one-year follow-up in Notophthalmus viridescens . Eguchi et al [10] reported that the lens in the Japanese newt, Cynops pyrrhogaster, attains the original size within 5 months of lentectomy.…”

Section: Introductionmentioning

confidence: 99%

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A Focus on the Optical Properties of the Regenerated Newt Lens

et al. 2013

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Lens regeneration studies in the adult newt suggest that molecular aspects of lens regeneration are complete within 5 weeks of lentectomy. However, very little is known about the optical properties of the regenerated lens. In an aquatic environment, the lens accounts for almost all of the refractive power of the eye, and thus, a fully functional lens is critical. We compared the optical properties of 9- and 26-week regenerated lenses in the red spotted newt, Notophthalmus viridescens, with the original lenses removed from the same eyes. At 9 weeks, the regenerated lenses are smaller than the original lenses and are histologically immature, with a lower density of lens proteins. The 9 week lenses have greater light transmission, but significantly reduced focal length and refractive index than the original lenses. This suggests that following 9 weeks of regeneration, the lenses have not recovered the functionality of the original lens. By 26 weeks, the transmission of light in the more mature lens is reduced, but the optical parameters of the lens have recovered enough to allow functional vision.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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A Focus on the Optical Properties of the Regenerated Newt Lens

et al. 2013

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“…The earliest studies began with observations of natural regenerative abilities in animals, with Thevenot, Du Verney and Perrault demonstrating lizard tail regeneration in 1686 (described in manuscript form in Thevenot et al, 1733 ) and Spallanzani – who also did pioneering stomach studies (reviewed in Saenz and Mills, 2018 ) – reporting salamander limb regeneration in 1768 ( Spallanzani, 1768 ). This was followed by experiments showing that amphibians of the order Urodela, including newts and salamanders, can regenerate retinas and lenses ( Wachs, 1920 ; Stone and Chace, 1941 ) as well as jaws and the olfactory apparatus ( Vallette, 1929 ). Studies became increasingly focused on the mechanisms driving this regeneration, with the idea that the mesoderm dedifferentiates to mediate the repair appearing by the mid 1900s ( Chalkley, 1954 ).…”

Section: Introductionmentioning

confidence: 99%

Plasticity of differentiated cells in wound repair and tumorigenesis, part I: stomach and pancreas

Burclaff

Mills

2018

Disease Models &Amp; Mechanisms

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For the last century or so, the mature, differentiated cells throughout the body have been regarded as largely inert with respect to their regenerative potential, yet recent research shows that they can become progenitor-like and re-enter the cell cycle. Indeed, we recently proposed that mature cells can become regenerative via a conserved set of molecular mechanisms (‘paligenosis’), suggesting that a program for regeneration exists alongside programs for death (apoptosis) and division (mitosis). In two Reviews describing how emerging concepts of cellular plasticity are changing how the field views regeneration and tumorigenesis, we present the commonalities in the molecular and cellular features of plasticity at homeostasis and in response to injury in multiple organs. Here, in part 1, we discuss these advances in the stomach and pancreas. Understanding the extent of cell plasticity and uncovering its underlying mechanisms may help us refine important theories about the origin and progression of cancer, such as the cancer stem cell model, as well as the multi-hit model of tumorigenesis. Ultimately, we hope that the new concepts and perspectives on inherent cellular programs for regeneration and plasticity may open novel avenues for treating or preventing cancers.

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Return of Vision in Transplanted Adult Salamander Eyes After Seven Days of Refrigeration

Stone¹

1946

Archives of Ophthalmology

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Experimental studies on the regenerating lens and the eye in adult Triturus viridescens

Cited by 23 publications

References 14 publications

A Focus on the Optical Properties of the Regenerated Newt Lens

A Focus on the Optical Properties of the Regenerated Newt Lens

Plasticity of differentiated cells in wound repair and tumorigenesis, part I: stomach and pancreas

Return of Vision in Transplanted Adult Salamander Eyes After Seven Days of Refrigeration

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