Experimental study and simulation of 63Zn production via proton induce reaction

Expanding the PET radioisotope universe utilizing solid targets on small medical cyclotrons

“…In both cases, 63 Zn production was maximized in the 13 to 12 MeV energy range. The primary target material for the reactions were natural copper foils 148 or natural copper that had been electroplated onto a suitable metal substrate such as gold. 146 When a natural copper foil was bombarded with a 16 MeV proton beam, the reported 63 Zn yield was 2470 MBq (mA h) À1 (i.e.…”

“…66.8 mCi (mA h) À1 ) with a purity exceeding 99.9%. 148 The primary impurities generated during bombardment were 64 Cu (t 1/2 : 12.7 h, 38.5% b À , 10.8% b + , 50.7% EC), 62 Zn (t 1/2 : 9.2 h, 8.2% b + , 91.8% EC), and 65 Zn (t 1/2 : 243.9 d, 1.4% b + , 98.6% EC). 144,148 The presence of the 65 Zn isotopic impurity is problematic for PET applications due to its long half-life.…”

“…148 The primary impurities generated during bombardment were 64 Cu (t 1/2 : 12.7 h, 38.5% b À , 10.8% b + , 50.7% EC), 62 Zn (t 1/2 : 9.2 h, 8.2% b + , 91.8% EC), and 65 Zn (t 1/2 : 243.9 d, 1.4% b + , 98.6% EC). 144,148 The presence of the 65 Zn isotopic impurity is problematic for PET applications due to its long half-life. To limit the production of this impurity, bombardments at beam energies exceeding 11 MeV have been recommended.…”

“…To limit the production of this impurity, bombardments at beam energies exceeding 11 MeV have been recommended. 148 Product purication. A method for isolating zinc from the irradiated natural copper targets is described by ref.…”

“…To limit the production of this impurity, bombardments at beam energies exceeding 11 MeV have been recommended. 148 …”