Existing slender masonry structures, such as Pagoda temples, towers, minarets and chimneys, exist all over the world and constitute a relevant part of the architectural and cultural heritage of humanity. Their protection against earthquakes is a topic of great concern among the earthquake engineering research community. This concern mainly arises from the strong damage or complete loss suffered by these types of structures when subjected to earthquake and also from the need and interest to preserve them. This chapter firstly presents a methodology for assessing the seismic vulnerability of slender masonry structures based on vulnerability index evaluation method. Secondly, presents the correlation between vulnerability index and Macroseismic method to estimate the physical damage in relationship with seismic intensity. Finally, presents implementation of the methodology to construct vulnerability curves, fragility curves and estimate losses.