Experimental Study of Cytoprotective Effect of Melatonin in Radiation Exposure

Пикалова, Л. В.; Legeza, V I; Иванов, М. Б.; Zhakovko, E. B.

doi:10.1007/s10517-011-1458-x

Cited by 14 publications

(3 citation statements)

References 5 publications

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“…For the 6 MV ionized X-ray, the dose maximum point was calculated at a depth of 1.6 cm from the skin surface, and the dose efficiency of the device was 1 MU =1 cGy. Melatonin (Melatonin Crystalline, Sigma-Aldrich Corporation) was dissolved in 1% ethanol solution and 1 mL was given to each animal 15 minutes before radiotherapy for the groups administered melatonin (17).…”

Section: Radiotherapy and Melatonin Applicationmentioning

confidence: 99%

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The Effects of Melatonin on the Bladder in the Application of Low and High Dose Rate Radiotherapy in the Abdominopelvic Region in Rats

Sapmaz¹,

Topkaraoglu²,

Başol³

et al. 2023

hamidiyemedj

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Background: To compare the changes caused by low and high dose rate radiotherapy in the bladder tissue of rats and to examine the effect of melatonin on the bladder tissue.Materials and Methods: 40 adult rats were randomly divided into five groups with 8 rats in each group. Radiotherapy and melatonin treatment were not applied to group 1 (G1) control group rats. A single dose of 8 Gy and 400 MU/min radiotherapy was applied to G2 and G3 group rats. A single dose of 8 Gy and 1400 MU/min radiotherapy was applied to G4 and G5 group rats. G3 and G5 group (treated groups) rats were given 50 mg/kg melatonin intraperitoneally 15 minutes before the radiotherapy application. Rats were sacrificed under anesthesia and bladder tissues were removed. Histopathological examination was performed on the samples stained with hematoxylin eosin and toluidine blue.Results: Number of mast cells was increased in G2 and G4 (p<0.01). In addition, edema and vascular congestion were observed in these groups. In G3 and G5, acute phase markers decreased compared to radiotherapy received groups. Conclusion:Bladder tissue degradation was observed in G2 and G4 compared to the control group. However, there was no difference in bladder tissue between the groups given two different doses. The acute phase markers of edema, number of mast cells, inflammatory cell infiltration, and vascular congestion in the bladder tissue of the groups administered melatonin decreased.

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Section: Radiotherapy and Melatonin Applicationmentioning

confidence: 99%

“…A single dose of 8 Gy and a high dose rate of 1400 MU/min radiotherapy was applied to the abdominopelvic regions of the rats in the G4 and G5 groups. In addition to G5 group rats, 50 mg/kg melatonin IP was given 15 minutes before radiotherapy (17).…”

Section: Radiotherapy and Melatonin Applicationmentioning

confidence: 99%

The Effects of Melatonin on the Bladder in the Application of Low and High Dose Rate Radiotherapy in the Abdominopelvic Region in Rats

Sapmaz¹,

Topkaraoglu²,

Başol³

et al. 2023

hamidiyemedj

View full text Add to dashboard Cite

show abstract

“…), оказывающих генопротективный эффект и снижающих косвенное повреждающее действие ионизирующего излучения, рассматривается синтетический аналог эпифизарного гормона-мелатонин [70,71]. На модели однократного облучения в дозах 2 и 4 Гр (до ~0,2-0,3 видовой LD50/30, крысы), характеризующейся выраженным повреждением генетического аппарата активно пролиферирующих клеток костного мозга и высоким уровнем хромосомных аберраций, увеличением интенсивности свободно-радикального окисления и активности антиоксидантной системы, профилактическое введение мелатонина в дозе 10 мг/кг уменьшало выраженность пострадиационных нарушений в хромосомах, снижало интенсивность процессов свободно-радикального окисления и усиливало общую антиоксидантную активность, что, по мнению авторов, свидетельствует о предотвращении или ослаблении развития в организме оксидативного стресса [72][73][74][75].…”

Section: антиоксиданты (природные и синтетические)unclassified

To the Question about Pharmacological Protection during Irradiation in Non-Infecting Doses: Maybe, Necessary? Communication 3. Review of the Experience of Studying and Prospects for the Use of Anti-Radiation Medicines

Ivanchenko¹,

Basharin²,

Drachev³

et al. 2023

MEDICAL RADIOLOGY AND RADIATION SAFETY

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Purpose: Review and systematization of data on the development of studies of drugs intended for protection against radiation in medium doses, assessment of the latest proposals and directions of pharmacological influence on radiation effects, incitement to discussion on the issue under consideration. Results: An analysis of domestic and foreign literature for the period of the 70–90s of the twentieth century and the latest period in relation to the prevention of tissue reactions and long-term effects of low-dose low-power irradiation was carried out, classes (groups) and samples of pharmaceuticals used were considered. Conclusions: 1. Very diverse previously proposed pharmaceuticals are still suitable, acting on various mechanisms of the genesis of the consequences of exposure to medium doses. 2. In recent years, substances (drugs) with receptor action, including genetically engineered products, as well as gene therapy agents, have been of primary interest, but they have been little studied as the means of choice due to their status as demonstration samples for use at medium doses. 3. Drugs of choice, made on the basis of many considerations over 30 years ago, until a replacement not be found.

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The role of melatonin on acute thyroid damage induced by high dose rate X-ray in head and neck radiotherapy

Aras

Tanzer

Can

et al. 2021

Radiation Physics and Chemistry

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Experimental Study of Cytoprotective Effect of Melatonin in Radiation Exposure

Cited by 14 publications

References 5 publications

The Effects of Melatonin on the Bladder in the Application of Low and High Dose Rate Radiotherapy in the Abdominopelvic Region in Rats

The Effects of Melatonin on the Bladder in the Application of Low and High Dose Rate Radiotherapy in the Abdominopelvic Region in Rats

To the Question about Pharmacological Protection during Irradiation in Non-Infecting Doses: Maybe, Necessary? Communication 3. Review of the Experience of Studying and Prospects for the Use of Anti-Radiation Medicines

The role of melatonin on acute thyroid damage induced by high dose rate X-ray in head and neck radiotherapy

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