Experimental study of inflammatory response and collagen morphometry with different types of meshes

Maeda, Carlos Toshinori; Neto, R. A Brandäo; Lopes-Filho, Gaspar Jesus; Linhares, Marcelo Moura

doi:10.1007/s10029-016-1513-7

Cited by 6 publications

(12 citation statements)

References 19 publications

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“…It is questioned whether at a later time, as Maeda et al . 20 described, this process of tissue inflammation could reduce and fibroplasia could improve, respectively, with the reduction of the inflammatory cellularity and maturation of the deposited collagen, which is consistent with the foreign body reaction that characterizes the implantation of synthetic meshes in the repair of hernias and abdominal wall defects.…”

Section: Discussionsupporting

confidence: 66%

“…Maeda et al . 20 , in a study with intraperitoneal implantation of polypropylene mesh with and without absorbable polydioxanone anti-adhesive barrier, concluded that a lightweight and macroporous polypropylene mesh favors an early more intense inflammatory reaction than the heavy-weight and microporous polypropylene mesh. Because it allows a greater flow of cells through the pores in this phase of prosthesis incorporation, which in turn contributes to a better collagen deposition and maturation at a later stage as the intensity of inflammation gets lower.…”

Section: Discussionmentioning

confidence: 99%

“…The histological analysis of the inflammatory tissue response was performed at the Department of Pathology of Universidade Federal de São Paulo, by a pathologist with experience on inflammatory responses and fibroplasia after the experimental implantation of synthetic meshes 15 , 16 , 20 , 21 . The sections stained with HE were examined using an Axio Scope.A1® (Carl Zeiss, Jena, Germany) optical microscope.…”

Section: Methodsmentioning

confidence: 99%

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Analysis of tissue inflammatory response, fibroplasia, and foreign body reaction between the polyglactin suture of abdominal aponeurosis in rats and the intraperitoneal implant of polypropylene, polypropylene/polyglecaprone and polyester/porcine collagen meshes

et al. 2021

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Purpose To compare tissue inflammatory response, foreign body reaction, fibroplasia, and proportion of type I/III collagen between closure of abdominal wall aponeurosis using polyglactin suture and intraperitoneal implant of polypropylene, polypropylene/polyglecaprone, and polyester/porcine collagen meshes to repair defects in the abdominal wall of rats. Methods Forty Wistar rats were placed in four groups, ten animals each, for the intraperitoneal implant of polypropylene, polypropylene/polyglecaprone, and polyester/porcine collagen meshes or suture with polyglactin (sham) after creation of defect in the abdominal wall. Twenty-one days later, histological analysis was performed after staining with hematoxylin-eosin and picrosirius red. Results The groups with meshes had a higher inflammation score (p < 0.05) and higher number of gigantocytes (p < 0.05) than the sham group, which had a better fibroplasia with a higher proportion of type I/III collagen than the tissue separating meshes (p < 0.05). There were no statistically significant differences between the three groups with meshes. Conclusions The intraperitoneal implant of polypropylene/polyglecaprone and polyester/porcine collagen meshes determined a more intense tissue inflammatory response with exuberant foreign body reaction, immature fibroplasia and low tissue proportion of type I/III collagen compared to suture with polyglactin of abdominal aponeurosis. However, there were no significant differences in relation to the polypropylene mesh group.

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Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Analysis of tissue inflammatory response, fibroplasia, and foreign body reaction between the polyglactin suture of abdominal aponeurosis in rats and the intraperitoneal implant of polypropylene, polypropylene/polyglecaprone and polyester/porcine collagen meshes

et al. 2021

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“…Pascual et al 37 also demonstrated that the use of meshes containing absorbable biological materials could increase the production of inflammatory mediators. Maeda et al 38 compared four different types of mesh: high-density PP, low-density PP, PP mesh encapsulated with oxidized cellulose-coated PDO, and expanded polytetrafluoroethylene. On postoperative day 28, the inflammatory scores of the low-density PP group were lower than those of all other groups 38 .…”

Section: Discussionmentioning

confidence: 99%

“…Maeda et al 38 compared four different types of mesh: high-density PP, low-density PP, PP mesh encapsulated with oxidized cellulose-coated PDO, and expanded polytetrafluoroethylene. On postoperative day 28, the inflammatory scores of the low-density PP group were lower than those of all other groups 38 . Our work also suggests that the use of absorbable biological materials, such as PDO, can prolong the inflammatory tissue reaction compared to PP.…”

Section: Discussionmentioning

confidence: 99%

Experimental Investigation on the Tissue Response Induced by Face-Lifting Mesh Suspension Thread in Rats

Kim

Kim²,

Park

et al. 2019

Ann Dermatol

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Background: Face-lifting procedures are often performed to hide the effects of aging. Thread-lifting, a minimally invasive technique for the correction of facial aging, has become increasingly popular, and various materials for the procedure have been developed. Objective: This study compared tissue responses to two types of threading sutures placed under rat skin: polypropylene (PP) monofilament mesh suspension thread (a novel face-lifting material) and polydioxanone (PDO) barbed thread. Methods: Eight rats each were assigned to the PP monofilament mesh suspension, PDO barbed thread, and control groups. Tissue reactions were evaluated 28 days after subcutaneous loading of the materials. Results: Significant increases in tensile strength and the mean area occupied by collagen fibers were evident in skin loaded with PDO barbed thread and PP monofilament mesh suspension thread compared to control skin (p＜0.05). Compared to sites loaded with PDO barbed thread, those loaded with PP monofilament mesh suspension thread showed a significant increase in the number of collagen fibers and a lower grade of inflammation (p＜0.05). Conclusion: PP monofilament mesh suspension thread has skin-rejuvenating effects comparable to those of PDO barbed thread, but induces a less severe inflammatory response. This indicates that it is a safe and effective material for use in thread-lifting procedures on aging skin. (Ann Dermatol 31(6) 645∼653, 2019

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Sublay repair results in superior mesh incorporation and histological fibrogenesis in comparison to onlay and primary suture in an experimental rat model

Leon

Manso

Abud

et al. 2018

Hernia

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Mesh positioning in sublay compartment was followed by increased adhesion development and provides a stronger mesh-tissue attachment, in addition, resulted in a different histological profile of the inflammation/repair substrate. The intensity of these findings was directly correlated, suggesting they could be the result of a common biological phenomenon. Our findings indicate that mesh placement following the retromuscular technique generates a superior repair response, and give clues to a better understanding of the superiority of sublay repair in achieving lower recurrence rates. Characterization of the cellular and molecular elements responsible for the superiority of this technique is in our view an essential prerequisite aiming for improvements in the therapeutic options for the treatment of this disease.

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Experimental study of inflammatory response and collagen morphometry with different types of meshes

Abstract: Inflammation scores decreased in all groups at 28 POD. Collagen deposition was higher for non-composite meshes at 28 POD.

Cited by 6 publications

References 19 publications

Analysis of tissue inflammatory response, fibroplasia, and foreign body reaction between the polyglactin suture of abdominal aponeurosis in rats and the intraperitoneal implant of polypropylene, polypropylene/polyglecaprone and polyester/porcine collagen meshes

Analysis of tissue inflammatory response, fibroplasia, and foreign body reaction between the polyglactin suture of abdominal aponeurosis in rats and the intraperitoneal implant of polypropylene, polypropylene/polyglecaprone and polyester/porcine collagen meshes

Experimental Investigation on the Tissue Response Induced by Face-Lifting Mesh Suspension Thread in Rats

Sublay repair results in superior mesh incorporation and histological fibrogenesis in comparison to onlay and primary suture in an experimental rat model

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