2017
DOI: 10.1051/epjconf/201714013002
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Experimental study of tensile strength of pharmaceutical tablets: effect of the diluent nature and compression pressure

Abstract: In the pharmaceutical field, tablets are the most common dosage form for oral administration in the world. Among different manufacturing processes, direct compression is widely used because of its economics interest and it is a process which avoids the steps of wet granulation and drying processes. Tablets are composed of at least two ingredients: an active pharmaceutical ingredient (API) which is mixed with a diluent. The nature of the powders and the processing conditions are crucial for the properties of th… Show more

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Cited by 10 publications
(4 citation statements)
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“…Nilai kekuatan tarik dapat dihitung dari gaya yang diperlukan untuk memecah tablet (harga kekerasan) dan luas area yang diberi gaya kompresi (diameter tablet). Secara umum, peningkatan gaya kompresi akan meningkatkan nilai kekuatan tarik [8,9].…”
Section: Kurva Kekuatan Tarikunclassified
“…Nilai kekuatan tarik dapat dihitung dari gaya yang diperlukan untuk memecah tablet (harga kekerasan) dan luas area yang diberi gaya kompresi (diameter tablet). Secara umum, peningkatan gaya kompresi akan meningkatkan nilai kekuatan tarik [8,9].…”
Section: Kurva Kekuatan Tarikunclassified
“…The tensile strength of tablets also differs according to the type of press used [ 16 ]. The tensile strength of the tablet is thus a fundamental parameter to consider, and is therefore tested as standard during the manufacturing process [ 17 ]. In order for the tablets to have the required tensile strength, it is necessary to ensure their correct compressibility.…”
Section: Introductionmentioning
confidence: 99%
“…This process compacts a material by releasing trapped air and reducing the gaps between particles, which improves the material’s properties. Tensile strength can be improved by the application of compressive force in forming pharmaceutical tablets [ 21 , 22 , 23 ]. Increasing the compaction pressure has also improved the mechanical properties of maize residue pellets [ 24 ] and biomass grass pellets [ 25 ].…”
Section: Introductionmentioning
confidence: 99%