Kawagoe's Law is an essential correlation in compartment fire research, which defines the relationship between the ventilation factor and maximum fuel burning of the compartment. Although this law has been widely used, there is still a lack of numerical validation and knowledge on the limiting conditions of its application. In this paper, a numerical study is conducted under full-scale compartment fire with different opening sizes and gas fuel supply rates using the LES model for validating Kawagoe's Law.The mass flow rate of inflow through the opening and the indoor heat release rate is focused during the numerical validation. Numerical results show that the inflow rate and indoor heat release rate comply well with Kawagoe's Law under ordinary openings with a small aspect ratio. However, Kawagoe's Law becomes less valid for openings with large aspect ratios and small-gap openings. The jet flame was observed in the case of openings with large aspect ratios under a high fuel supply rate. For compartment fires with small gaps, a breathing process, i.e., the periodical suppression and revitalization of the fire, is modeled. This work provides practical guidance for modeling compartment fires and paving the way for constructing a numerical compartment fire database.