A comprehensive numerical investigation into the cross-sectional behaviour and ultimate capacity of non-slender welded I-sections, made of both normal and high strength steels (NSS and HSS), under combined compression and uniaxial bending is presented. Finite element (FE) models were initially established and validated against test results collected from the literature. Subsequently, parametric studies were conducted using the validated FE models to generate extensive numerical data considering different steel grades, cross-section geometries and loading combinations. The obtained numerical data, together with the test results collected from the literature, were utilised to assess the accuracy of the traditional European (EC3) and North American (AISC) design provisions, as well as the Continuous Strength Method (CSM), for NSS and HSS welded I-sections under combined loading. The assessment indicated that the CSM was able to provide more accurate and consistent resistance predictions than the current EC3 and AISC design provisions owing to its ability to capture the spread of plasticity and strain hardening in a systematic, mechanics-based manner. Finally, the reliability levels of the different design methods were statistically evaluated in accordance with EN 1990:2002.